2012 Fiscal Year Final Research Report
Investigation for NK cell subset homeostasis and function in tumor mocroenvironment
| Project/Area Number |
23701073
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | University of Toyama (2012)
The University of Tokyo (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | NK細胞 / がん / がん転移 |
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| Research Abstract |
CD27hi NK subset was the major population within tumor-infiltrating NK cells to be an early source of IFN-γ. Endogenous IFN-g was critical for NK cell recruitment into the tumor site and further critical effector molecule for anti-metastatic activity of NK cells. TRAIL, the effector molecule of NK cells, contrary played pro-metastatic role by providing inflammatory signal into tumor cells.
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