2013 Fiscal Year Final Research Report
Development of cancer vaccine therapy based on the control of regulatory T cells
| Project/Area Number |
23701075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MIYAZAWA Motoki 和歌山県立医科大学, 医学部, 学内助教 (90549734)
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| Project Period (FY) |
2011 – 2013
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| Keywords | regulatory T cell / VEGFR2 |
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| Research Abstract |
The proportion of Tregs in the peripheral blood decreased in patients with pancreatic cancer who administered VEGFR2-peptide and had positive VEGFR2-specific CTL responses(Cancer Sci. 2010). We hypothesized that VEGFR2-specific CTL had cytotoxicity against Tregs overexpressing VEGFR2(Eur.J.Immunol. 2010). However, this study showed that there was no difference in the cytotoxicity of VEGFR2-specific CTL against Tregs with or without VEGFR2 expression. It is necessary to investigate the correlation between the VEGFR2-specific cytotoxicity against Tregs expressing VEGFR2 and the expression of MHC Class I on the Tregs for the future.
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Research Products
(35 results)
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[Journal Article] Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2)2014
Author(s)
Yoshimura S, Tsunoda T, Osawa R, Harada M, Watanabe T, Hikichi T, Katsuda M, Miyazawa M, Tani M, Iwahashi M, Takeda K, Katagiri T, Nakamura Y, Yamaue H
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Journal Title
PLoS One.
Volume: 9(1) eCollection 2014
Pages: e85267
Peer Reviewed
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[Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer2014
Author(s)
Yamaue H, Satoi S, Kanbe T, Miyazawa M, Tani M, Kawai M, Hirono S, Okada K, Yanagimoto H, Kwon AH, Mukouyama T, Tsunoda H, Chijiiwa K, Ohuchida J, Kato J, Ueda K, Yamaguchi T, Egawa S, Hayashi K, Shirasaka T
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Journal Title
Cancer Chemother Pharmacol.
Volume: 73(1)
Pages: 97-102
Peer Reviewed
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[Journal Article] Inhibition of IL-17A in tumor microenvironment augments cytotoxicity of tumor-infiltrating lymphocytes in tumor-bearing mice2013
Author(s)
Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T, Yamaue H
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Journal Title
PLoS One.
Volume: 8(1)
Pages: e53131
Peer Reviewed
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[Journal Article] Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma2012
Author(s)
Shimizu A, Hirono S, Tani M, Kawai M, Okada K, Miyazawa M, Kitahata Y, Nakamura Y, Noda T, Yokoyama S, Yamaue H
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Journal Title
Cancer Sci.
Volume: 103(4)
Pages: 739-46
Peer Reviewed
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