2013 Fiscal Year Final Research Report
Clinical impact of down-regulated plasma miR-92a levels in non-hodgkin's lymphoma
| Project/Area Number |
23701088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 非ホジキンリンパ腫 / 血清miRNA / miR-92a / 診断マーカー |
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| Research Abstract |
To evaluate the clinical relevance of the miR-92a in plasma obtained from non-Hodgkin's lymphoma patients, because miR-92 miRNA plays a crucial role in lymphogenesis, as well as tumorigenesis in lymphoid tissue. We evaluated plasma miR-92a value; MicroRNA Assays with modifications with non-Hodgkin's lymphoma and compared results with healthy subjects. Plasma miR-92a values in non-Hodgkin's lymphoma were extremely low, compared to healthy subjects. At the time of diagnosis The down-regulated plasma miR-92a increased in the complete response phase, reaching normal control levels, and again becoming down-regulated in the relapse phase. In non-Hodgkin's lymphoma patients, while a decreased level of plasma miR-92a was evident, indicating that the discrepancy lymph circulating miR-92a might be an important clinical issue. The plasma miR-92a value could be a novel biomarker for monitoring lymphoma patients, especially in those with indolent lymphoma.
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Research Products
(10 results)
