Production of long-lived radioisotopes using small cyclotron for labeling of biomacromolecules

2012 Fiscal Year Final Research Report

• Project/Area Number: 23701091
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor diagnosis
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KANAYAMA Yousuke 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (60435641)
• Project Period (FY): 2011 – 2012
• Keywords: 89Zr / 小型サイクロトロン / RI 製造 / PET イメージング / 抗体 / 65Zn

Research Abstract

For development of biomacromolecular PET probes which require long-term tracking, a production method for long-lived positron-emitting metal radionuclides was investigated using small cyclotron. We established a convenient method for yttrium-foil irradiation with a gold disc support and succeeded the production of ^<89>Zr, which has a half-life of 78.4 hours. In a PET imaging of tumor-bearing mouse with the ^<89>Zr-labeled antibody, high accumulation was observed in tumor regions even 8 days after injection. This metal-foil target irradiation method has a potential for various radioisotope productions.