• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Production of long-lived radioisotopes using small cyclotron for labeling of biomacromolecules

Research Project

  • PDF
Project/Area Number 23701091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnosis
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KANAYAMA Yousuke  独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (60435641)

Project Period (FY) 2011 – 2012
Keywords89Zr / 小型サイクロトロン / RI 製造 / PET イメージング / 抗体 / 65Zn
Research Abstract

For development of biomacromolecular PET probes which require long-term tracking, a production method for long-lived positron-emitting metal radionuclides was investigated using small cyclotron. We established a convenient method for yttrium-foil irradiation with a gold disc support and succeeded the production of ^<89>Zr, which has a half-life of 78.4 hours. In a PET imaging of tumor-bearing mouse with the ^<89>Zr-labeled antibody, high accumulation was observed in tumor regions even 8 days after injection. This metal-foil target irradiation method has a potential for various radioisotope productions.

URL: 

Published: 2014-08-29   Modified: 2014-10-07  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi