Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23701098
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical oncology
• Research Institution: Kanazawa University
• Principal Investigator: SUNAGOZAKA Hajime 金沢大学, 大学病院, 助教 (90595836)
• Project Period (FY): 2011 – 2013
• Keywords: 肝細胞癌 / C19ORF10 / SAGE

Research Abstract

This time, we succeeded in the full cloning of new molecular target C19ORF10 activated in hepatocellular carcinoma by the comprehensive gene analysis which used the SAGE library.C19ORF10 is a growth factor through PI3 K/Akt and MAPK/Erk1/2. Cancer cell growth was suppressed by adding the anti-C19ORF10 antibody.
This result was submitted to International Journal of Cancer and published on Int J Cancer. 2011 Oct 1;129(7):1576-85.
Furthermore, we created the ELISA plate to C19ORF10 serum-concentration measurement and examine to clinical application of C19ORF10.

Research Products

• [Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomisedcontrolled trial (2014)
  • Author(s): Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato K, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S
  • Journal Title: Diabetologia Volume: May;57(5) Pages: 878-90
  • DOI: 10.1007/s00125-013-3149-9
  • Peer Reviewed
• [Journal Article] Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinomaafter sorafenib (2013)
  • Author(s): Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S
  • Journal Title: Hepatol Res Volume: Oct 31 Pages: 1-7
  • DOI: 10.1111/hepr.12266
  • Peer Reviewed
• [Journal Article] Gene expression profiling of hepatitis B-and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling (2013)
  • Author(s): Ueda T, Honda M, Horimoto K, Aburatani S, Saito S, Yamashita T, Sakai Y, Nakamura M, Takatori H, Sunagozaka H, Kaneko S
  • Journal Title: Genomics Volume: Apr;101(4) Pages: 238-48
  • DOI: 10.1016/j.ygeno.2013.02.007
  • Peer Reviewed
• [Journal Article] Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma (2013)
  • Author(s): Mizukoshi E, Yamashita T, Arai K, Sunagozaka H, Ueda T, Arihara F, Kagaya T, Yamashita T, Fushimi K, Kaneko S
  • Journal Title: Hepatology Volume: Apr;57(4) Pages: 1448-57
  • DOI: 10.1002/hep.26153
  • Peer Reviewed
• [Journal Article] 肝深部病変に位置する肝腫瘍に対する脈管損傷を回避するRFAの工夫 (2013)
  • Author(s): 砂子阪肇,山下竜也,北原征明,荒井邦明,金子周一
  • Journal Title: 医学と薬学 Volume: 70巻2号 Pages: 245-48
  • Peer Reviewed
• [Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression (2012)
  • Author(s): Takeshita Y, Takamura T, Inoue O, Okumura,Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S
  • Journal Title: Intern Med Volume: 51(1) Pages: 79-82
  • Peer Reviewed
• [Journal Article] Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance : implications fortype 2 diabetes (2012)
  • Author(s): Takeshita Y, Takamura T, Kita Y, Ando H, Ueda T, Kato K, Misu H, Sunagozaka H, Sakai Y,Yamashita T, Mizukoshi E, Honda M, Kaneko S
  • Journal Title: Metabolism. Volume: 61(10) Pages: 1388-94
  • DOI: 10.1016/j.metabl
  • Peer Reviewed
• [Journal Article] Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinomadevelopment (2012)
  • Author(s): Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H,Tanaka T, Fausto N, Kaneko S
  • Journal Title: Cancer Res Volume: 72(17) Pages: 4459-71
  • DOI: 10.1158/0008-5472.CAN-12-0028
  • Peer Reviewed
• [Journal Article] A case report of S-1 monotherapy for advanced hepatocellular carcinoma (2012)
  • Author(s): Yamashita T, Arai K, Terashima T, Sunagozaka H, Shimakami T, Yamashita T, Mizukoshi E, Sakai A, Honda M, Kaneko S
  • Journal Title: Gan To Kagaku Ryoho. Volume: 39(9) Pages: 1435-7
  • Peer Reviewed
• [Presentation] Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma with stemcell features (2013)
  • Author(s): Hajime Sunagozaka, Taro Yamashita, Naoki Oishi, Takehiro Hayashi, Hajime Takatori, Tetsuro Shimakami, Kazuya Kitamura, Kuniaki Arai, Takashi Kagaya, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda,Shuichi Kaneko
  • Organizer: 第64回米国肝臓学会
  • Place of Presentation: Washington D.C(USA)
  • Year and Date: 2013-11-05
• [Presentation] 肝細胞癌における血清 Dickkopf-1の新規バイオマーカーとしての可能性 (2013)
  • Author(s): 砂子阪肇,山下太郎,金子周一
  • Organizer: 第17回日本肝臓学会(JDDW2013)
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2013-10-09
• [Presentation] 肝癌サーベイランスにおけるバイオマーカーの再評価肝細胞癌における血清Dickkopf-1の新規バイオマーカーとしての可能性 (2013)
  • Author(s): 砂子阪肇 ,山下太郎 ,金子周一
  • Organizer: 第49回日本肝癌研究会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2013-07-11
• [Presentation] ソラフェニブ治療後症例に対する肝動注化学療法の安全性と有効性に関する検討 (2013)
  • Author(s): 砂子阪肇,山下竜也,荒井邦明,堀井里和,飯田宗穂,北原征明,大石尚毅,鷹取元,島上哲朗,北村和哉,加賀谷尚史,山下太郎,酒井佳夫,水腰英四郎,金子周一
  • Organizer: 第8回日本肝がん分子標的治療研究会
  • Place of Presentation: 和倉温泉「加賀屋」(石川)
  • Year and Date: 2013-06-22
• [Presentation] Efficacy and safety of sorafenib treatment in patients with hepatocellular carcinoma : a multi-center retrospective study in Japan (2012)
  • Author(s): Hajime Sunagozaka, Tatsuya Yamashita, Kuniaki Arai, Shuichi Kaneko
  • Organizer: 第63回アメリカ肝臓学会
  • Place of Presentation: ボストンコンベンションセンター(USA)
  • Year and Date: 2012-09-17
• [Presentation] 異なる画像所見を呈する多血結節を造影超音波にて比較鑑別できたC型慢性肝炎の一例 (2012)
  • Author(s): 砂子阪肇 山下竜也 荒井邦明 金子周一
  • Organizer: 第33回超音波医学会中部地方会
  • Place of Presentation: 愛知医科大学(愛知県)
  • Year and Date: 2012-09-09
• [Presentation] 肝細胞癌に対する経皮的ラジオ波焼灼療法の初発・再発時肝予備能に関する検討 (2012)
  • Author(s): 砂子阪肇 山下竜也 荒井邦明 金子周一
  • Organizer: 第48回肝臓総会
  • Place of Presentation: ホテル日航金沢(石川県)
  • Year and Date: 2012-06-08