2013 Fiscal Year Final Research Report
Investigation of Nanospace at Biological Membrane/Biological Solution Interfaces by Three-Dimensional Scanning Force Microscopy
| Project/Area Number |
23710142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Kanazawa University |
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Principal Investigator |
ASAKAWA Hitoshi 金沢大学, バイオAFM先端研究センター, 助教 (90509605)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 原子間力顕微鏡 / 脂質二重膜 / 生体膜 / 水和構造 / ナノ計測 |
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| Research Abstract |
In this project, I have developed a closed fluid cell with liquid-sealing mechanism to improve the stability and the reproducibility of three-dimensional scanning force microscopy (3D-SFM). The results showed the applicability of the developed closed fluid cell to atomic-scale AFM experiments. In addition, I demonstrated the 3D visualization of hydration structures and lipid headgroups at the interface between DPPC bilayer and water by 3D-SFM. The results suggest the applicability of 3D-SFM imaging to molecular-scale studies of biological membrane/biological solution interfaces.
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