2012 Fiscal Year Final Research Report
Analysis of molecular mechanism of cohesin acetylation by ESCO1 and ESC02
| Project/Area Number |
23710213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Genome biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
BANDO Masashige 東京大学, 分子細胞生物学研究所, 助教 (90360627)
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| Project Period (FY) |
2011 – 2012
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| Keywords | エピゲノム |
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| Research Abstract |
We found that Esco1 acetylates cohesin through its N-terminalinteraction with Pds5. ChIP-seq analysis of ESCO1 showed that it co-localizes with cohesinthroughout the cell cycle. On the other hand acetylation of cohesin by ESCO2 requires Mcmhelicases. Thus Esco2 in human, just like Eco1 in yeast, seems to establish sisterchromatids cohesion during DNA replication progression
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Research Products
(3 results)
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[Journal Article] Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.2012
Author(s)
Suzuki T, Ota Y, Ri M, Bando M, Gotoh A, Itoh Y, Tsumoto H, Tatum PR, Mizukami T, Nakagawa H, Iida S, Ueda R, Shirahige K, Miyata N
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Journal Title
J Med Chem.
Volume: 55
Pages: 9562-9575
Peer Reviewed
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[Journal Article] Lombardi PM,Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T,Krantz ID2012
Author(s)
Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T
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Journal Title
Shirahige K..,HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle., Nature.
Volume: 489
Pages: 313-317
Peer Reviewed
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