2013 Fiscal Year Final Research Report
Molecular mechanism of H2O2 and H2 on Wnt signaling pathway
| Project/Area Number |
23710253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagoya University |
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Principal Investigator |
OHKAWARA Bisei 名古屋大学, 高等研究院(医), 特任講師 (80589606)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 過酸化水素 / 分子状水素 / Wntシグナル |
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| Research Abstract |
Hydrogen peroxide (H2O2) is reactive oxygen species (ROS). Molecular hydrogen (H2) is thought to cancel the ROS effects in disease model mice, however the molecular mechanism of H2 remain elusive. Wnt signaling is involved in several phenomena in vivo.
Here, for the purpose to know the molecular mechanism of H2O2 and H2 effects, we analyzed the Wnt signaling activity in cells treated with these factors. Within cultured cells, H2 partially cancelled H2O2 effects on Wnt signaling in treatment duration-manner. The results suggest that H2 have effects on the signaling pathway both in H2O2-dependent manner and H2O2–independent manner.
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[Journal Article] LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner2014
Author(s)
Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K
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Journal Title
Hum Mol Genet.
Volume: Apr 1;23(7)
Pages: 1856-68
DOI
Peer Reviewed
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