2012 Fiscal Year Final Research Report
Construction of a photoregulating system for self-assembly proteins
| Project/Area Number |
23750179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tohoku University |
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Principal Investigator |
UI Mihoko 東北大学, 多元物質科学研究所, 助教 (30549580)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 光応答性蛋白質 / 自己集合蛋白質 / photoactive yellow protein / alpha-hemolysin / 光制御 |
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| Research Abstract |
We constructed two types of photo-controlled nano-pore devices based on PYP photoreceptor-fused staphylococcal pore-forming toxin alpha-hemolysin. The both PYP-fused devices had the similar photocycle as wild type PYP and inhibited the transmission efficiency of ions through the sheep red blood cells membrane under light irradiation. These PYP-fused devices will serve molecular basis for nano-pore devices of which activity is easy to be arbitrarily tuned by light irradiation.
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