2012 Fiscal Year Final Research Report
Elucidation of molecular mechanism of polyglutamine protein induced dysfunction of mitochondrial membrane and dynamics
| Project/Area Number |
23770108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Structural biochemistry
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| Research Institution | Kurume University |
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Principal Investigator |
TADATO Ban 久留米大学, 分子生命科学研究所, 助教 (00579667)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経変性疾患 / ポリグルタミン蛋白質 / ミスフォールディング / アミロイド線維 / ミトコンドリア / 脂質膜 / 膜ダイナミクス |
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| Research Abstract |
Polyglutamine disease is neurodegenerative disorder caused by protein misfolding and aggregation. In this study, we analyzed the effect of conformational change of model polyglutamine protein to its enzymatic function and interaction with model lipid membrane. We show the enzymatic activity of polyglutamine protein is suppressed by soluble amyloidogenic conformer. This finding indicates that conformational transitions of polyglutamine protein inhibit physiological function and induce cellular dysfunction.
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Research Products
(1 results)
