2013 Fiscal Year Final Research Report
Molecular mechanisms of membrane dynamics at early endosomes
| Project/Area Number |
23770148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Women's Medical University (2012-2013)
Okayama University (2011) |
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Principal Investigator |
TANABE KENJI 東京女子医科大学, 医学部, テニュアトラック准教授 (80423341)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞内膜輸送 / エンドソーム / 細胞骨格 / 脂質膜 |
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| Research Abstract |
Early endosomes are intracellular sorting station for internalized molecules. In this study, we tried to identify some associated proteins and analyzed its molecular functions at early endosomes. As a result, dynamin, cotactin and actin cytoskeleton were identified as key players at at early endosomes. Moreover, we found that a phosphatidylinositol kinase, PI4KIIalpha, and its enzymatic product, PI(4)P, localized on early endosomes and are required for the transport from early endosomes. These results could be an important knowledge to understand the molecular mechanism of early endosomes.
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[Journal Article] The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis2013
Author(s)
Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M
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Journal Title
Mol. Biol. Cell
Volume: 24
Pages: 2633-44
DOI
Peer Reviewed
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[Journal Article] Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia2013
Author(s)
Kon, S., Minegishi, N., Tanabe, K., Watanabe, T., Funaki, T., Wong, W. F., Sakamoto, D., Higuchi Y., Kiyonari H., Asano K., Iwakura Y., Fukumoto M., Osato M., Sanada M., Ogawa S., et al.
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Journal Title
Journal of Clinical Investigation
Volume: 123
Pages: 1123-37
DOI
Peer Reviewed
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