2012 Fiscal Year Final Research Report
Analysis of endopeptidase reactions involved in ERAD
| Project/Area Number |
23770162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HOSOMI Akira 独立行政法人理化学研究所, 糖鎖代謝学研究チーム, 特別研究員 (60525864)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ERAD / 糖タンパク質 / PNGase / エンドペプチダーゼ |
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| Research Abstract |
ER quality control (ERQC) is a protein surveillance system, which scrutinizes the folding status of newly synthesized proteins in the ER. In this system, aberrant proteins, which fail to form a functional folding/complex, will be degraded by a degradation pathway called ER-associated degradation (ERAD). In this study, novel endopeptidase reaction involved in ERAD process was analyzed. Ste24 is identified as a candidate of “ERAD endopeptidase”.
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