2012 Fiscal Year Final Research Report
Identifying the active form of FGF19 based on the fact that beta-Klotho recognizes a distinct sugar motif.
| Project/Area Number |
23770166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | 公益財団法人先端医療振興財団 (2012)
Foundation for Biomedical Research and Innovation (2011) |
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Principal Investigator |
MAEDA Ryota 公益財団法人先端医療振興財団, 先端医療センター, 研究員 (50432399)
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| Co-Investigator(Renkei-kenkyūsha) |
IMURA Akihiro (60362513)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞・組織 / シグナル伝達 / 生理活性 / 蛋白質 / 糖鎖 |
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| Research Abstract |
We have proposed that specific carbohydrate modifications play an important role in physiological activities of the endocrine fibroblast growth factors, including FGF-23, FGF 9, and FGF-21. Based on our previous study that a sugar modification increases activities of FGF-3, we tried to identify any modifications that enhance activities of other endocrine fibroblast growth factors, FGF-19 and FGF-21. Consequently, we show that a distinct terminal glucuronic acid sugar modification is sufficient for proper activity of these growth factors.
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Research Products
(19 results)
