2012 Fiscal Year Final Research Report
Molecular mechanism of repression of rDNA transcription by KDM2A in response to starvation
| Project/Area Number |
23770209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
TANAKA Yuji 高崎健康福祉大学, 薬学部, 助教 (90453422)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写 / ヒストン修飾 / リボソーム RNA / JmjC |
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| Research Abstract |
In previous study, we found that histone demethylase KDM2Adecreases histone H3K36me2 on rDNA promoter and represses rDNA transcription during starvation. Here, I had researched about molecular mechanisms of KDM2A to repress rDNA transcription. I showed that insulin or glucose treatment suppressed demethylation activity of KDM2A in rDNA promoter and repression of rDNA transcription in starved cells. Moreover, CXXC domain in KDM2A was required to demethylate H3K36me2 in rDNA promoter and to repress rDNA transcription during starvation.
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