2012 Fiscal Year Final Research Report
Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
| Project/Area Number |
23770227
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 酸化ストレス / ミトコンドリア / 細胞内情報伝達 / 細胞死 / 線虫 / ヒト培養細胞 |
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| Research Abstract |
An experimental assay system was employed to generate excessive ROS in the mitochondria in a precisely controlled spatio-temporal manner. Using mammalian cells and worm C. elegans generating mitochondrial ROS, I analyzed the stress response and the molecular mechanism induced by mitochondrial ROS in vitro and in vivo. I revealed that factors involved in the mitochondrial permeability transition (Cyclophilin D and Ca++) were contributed to the mitochondrial oxidative stress response and that mitochondrial ROS affected the development of C.elegans.
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