2013 Fiscal Year Final Research Report
Second messenger systems required for epithelial morphogenesis in vivo
| Project/Area Number |
23770261
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SUZUKI Makoto 基礎生物学研究所, 形態形成研究部門, 助教 (10533193)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経管閉鎖 / 頂端収縮 / カルシウム |
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| Research Abstract |
To understand function and regulatory mechanism of second messenger systems in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that intracellular calcium ion signaling positively regulates apical constriction, one of the important cellular behaviors in the neuroepithelial cells. We also found that extracellular ATP was involved in calcium-mediated apical constriction. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.
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