2012 Fiscal Year Final Research Report
Elucidation of cell position-dependent Hippo-pathway regulatorymechanisms in preimplantation embryos
| Project/Area Number |
23770265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞分化 / Hippo 経路 / 細胞接着 / Angiomotin / カドヘリン / カテニン / マウス / 着床前 |
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| Research Abstract |
Hippo signaling in preimplantation embryos exhibits a cellposition-dependent difference in strength. Inner and outer cells show strong and weaksignaling, respectively. This research clarified the mechanisms of the Hippo pathwayactivation by an adhesion-associated protein Angiomotin and its suppression by cellpolarity. This is the machinery which converts cell position into differential strengthof Hippo signaling. This research uncovered a key problem of the Hippo pathway regulation,which contributes to the progress of the relevant fields
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