2012 Fiscal Year Final Research Report
Research for lymphatic lipid transport regulatory genes and the development of the prevention of metabolic syndrome
| Project/Area Number |
23780138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIROUCHI Bungo 九州大学, 大学院・農学研究院, 助教 (00548018)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脂質輸送 / リンパ流量 / リンパ管 / 半永久胸管リンパカニュレーション法 |
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| Research Abstract |
We tried to explore substances affecting lymph flow and lymphatic lipid transport in thoracic lymph duct-cannulated rats and then to identify lymphatic lipid transport regulatory-related genes in the thoracic lymph duct. As the results, we found that ezetimibe, a cholesterol absorption inhibitor, reduces lymphatic transport of esterified-cholesterol and β-epoxycholesterol and that guar gum and TO901317, a synthetic ligand of liver X receptor (LXR), reduces lymph flow and lymphatic lipid transport.Using a DNA microarray technique, we explored lymphatic lipid transport regulatory-related genes in the thoracic lymph duct of guar gum- or TO901317-fed rats. As the results, we identified 4 candidate genes for lymphatic lipid transport in the thoracic lymph duct.
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