2012 Fiscal Year Final Research Report
Environmental Control for Rapid Production of an Influenza VaccineAntigen using Plants
| Project/Area Number |
23780255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Agricultural environmental engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUDA Ryo 東京大学, 大学院・農学生命科学研究科, 講師 (20547228)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 一過性遺伝子発現 / ウイルスベクター / インフルエンザワクチン / 環境調節 / ベンサミアナタバコ / ヘマグルチニン / 気温 / 光合成有効光量子束密度 |
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| Research Abstract |
Effects of plant growing conditions such as physical environment on the level of recombinant influenza hemagglutinin accumulation were investigated in a viral vector-based transient gene expression system. We found that air temperature post viral-vector inoculation was an important environmental variable for enhancing hemagglutinin productivity. We also suggested that vacuum infiltration of plant aerial parts can be improved for increasing the efficiency of vector inoculation.
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