Study of local immune cell function that regulates corpus luteum development in the cow

2012 Fiscal Year Final Research Report

• Project/Area Number: 23780288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Jichi Medical University
• Principal Investigator: SHIRASUNA Koumei 自治医科大学, 医学部, 助教 (20552780)
• Project Period (FY): 2011 – 2012
• Keywords: ウシ / 免疫 / 黄体

Research Abstract

Corpus luteum (CL) formation and regression resembles an inflammatory response due to the influx of immune cells. Neutrophils migrate into the early CL partially due to its major chemoattractant interleukin-8 produced at high levels in the CL, and neutrop

Research Products

• [Journal Article] Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows (2012)
  • Author(s): Shirasuna K, Matsumoto H, Kobayashi E, Nitta A, Haneda S, Matsui M, Kawashima C, Kida K, Shimizu T, Miyamoto A
  • Journal Title: J Reprod Dev Volume: 58 Pages: 84-90
• [Journal Article] Rapid accumulation of polymorphonuclear neutrophils in the corpus luteum during prostaglandin F2α-induced luteolysis in the cow (2012)
  • Author(s): Shirasuna K*, Jiemtaweeboon S, Raddatz S, Nitta A, Schuberth HJ, Bollwein H, Shimizu T, Miyamoto A
  • Journal Title: PLoS ONE Volume: 7 Pages: 29054
• [Journal Article] Possible action of vasohibin-1 as an inhibitor in the regulation of vascularization of the bovine corpus luteum. (2012)
  • Author(s): Shirasuna K*, Kobayashi A, Nitta A, Nibuno S, Sasahara K, Shimizu T, Bollwein H, Miyamoto A
  • Journal Title: Reproduction Volume: 143 Pages: 491-500
• [Journal Article] Expression of prostaglandin F2αreceptor and its isoforms in the bovine corpus luteum during the estrous cycle and PGF2α-induced luteolysis. (2012)
  • Author(s): Shirasuna K, Akabane Y, Beindorff N, Nagai K, Sasaki M, Shimizu T, Bollwein H, Meidan R, Miyamoto A
  • Journal Title: Domest Anim Endocrinol Volume: 43 Pages: 227-238
• [Journal Article] Evidence that polymorphonuclear neutrophils infiltrate into the developing corpus luteum and promote angiogenesis with interleukin-8 in the cow (2011)
  • Author(s): Jiemtaweeboon S, Shirasuna K*, Nitta A, Kobayashi A, Schuberth HJ, Shimizu T, Miyamoto A
  • Journal Title: interleukin-8 in the cow. Volume: 9 Pages: 79
• [Journal Article] Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow (2011)
  • Author(s): Nitta A, Shirasuna K*, Haneda S, Matsui M, Shimizu T, Matsuyama S, Kimura K, Schuberth HJ, Miyamoto A.
  • Journal Title: Reproduction Volume: 142 Pages: 879-892
• [Presentation] ウシ妊娠認識時期でのインターフェロンτによる黄体内好中球動員機構 (2011)
  • Author(s): 白砂孔明,松本悠,Jiemtaweeboon S,羽田真悟, 松井基純,Bollwein H,清水隆,宮本明夫
  • Organizer: 第104回日本繁殖生物学会
  • Place of Presentation: 岩手
  • Year and Date: 20110900
• [Presentation] Recruitment of neutrophils within the pregnant corpus luteum in response to interferon tau at the maternal recognition period in the cow (2011)
  • Author(s): Shirasuna K, Matsumoto H, Sinnenard J, Kobayashi A, Haneda S, Matsui M, Shimizu T, Bollwein H, Miyamoto A
  • Organizer: 44th annual meeting; Society for the Study of Reproduction
  • Place of Presentation: Oregon (USA).
  • Year and Date: 20110700
• [Presentation] High number of neutrophils exists in the developing corpus lutem and promotes angiogenesis and progesterone secretion in the cow. (2011)
  • Author(s): Sinnenard J, Shirasuna K, Kobayashi A, Schuberth HJ, Shimizu T, Bollwein H, Miyamoto A
  • Organizer: 44th annual meeting; Society for the Study of Reproduction
  • Place of Presentation: Oregon (USA)
  • Year and Date: 20110700
• [Presentation] Capacity of the corpus luteum to migrate mononuclear immune cells and their effect on luteal function in the cow (2011)
  • Author(s): Kobayashi A, Shirasuna K, Sinnenard J, Shimizu T, Bollwein H, Miyamoto A
  • Organizer: 44th annual meeting; Society for the Study of Reproduction
  • Place of Presentation: Oregon (USA)
  • Year and Date: 20110700
• [Presentation] The corpus luteum development regulated by angiogenic factors and polymorphonuclear neutrophils in the cow (2011)
  • Author(s): Shirasuna K, Jiemtaweeboon S, Nitta A, Shimizu T, Miyamoto A.
  • Organizer: JSPS Japan-Poland Joint Seminar
  • Place of Presentation: Iwate Aiina hall (Iwate University), Iwate
  • Year and Date: 20110000
• [Presentation] The predominant infiltration of neutrophils at the very early stage of development into the cyclic bovine corpus luteum (2010)
  • Author(s): Jiemtaweeboon S,白砂孔明,小林明由未, Schuberth HS, 清水隆,宮本明夫
  • Organizer: 第103回日本繁殖生物学会
  • Place of Presentation: 青森
  • Year and Date: 20100900