Mechanism of interspecies transmission of avian influenza viruses

2012 Fiscal Year Final Research Report

• Project/Area Number: 23780304
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: OKAMATSU Masatoshi 北海道大学, 大学院・獣医学研究科, 助教 (00507163)
• Project Period (FY): 2011 – 2012
• Keywords: 人獣共通感染症 / 鳥インフルエンザ / 種間伝播 / レセプター / 糖鎖 / ニワトリ

Research Abstract

Receptor specificity of influenza A viruses and glyco receptors expressed host tissues were analyzed. Using lectins and antibodies that recognize terminal sialic acid and structure of glycoconjugates, distribution of the receptors in the epithelial cells of birds and mammals were determined. On chicken epithelial cells, unique glyco receptor was detected and virus that efficiently grow in chickens recognized the receptor.

Research Products

• [Journal Article] Proteins of duck influenza virus responsible for acquisition of pathogenicity in chickens. (2013)
  • Author(s): Yamamoto N, Soda K, Sakoda Y, Okamatsu M, Kida H.
  • Journal Title: Virus Res Volume: 173 Pages: 294-298
  • Peer Reviewed
• [Journal Article] Potency of an inactivated influenza vaccine prepared from a non-pathogenic H5N1 virus against a challenge with antigenically drifted highly pathogenic avian influenza viruses in chickens. (2013)
  • Author(s): Shichinohe S, Okamatsu M, Yamamoto N, Noda Y, Nomoto Y, Honda T, Takikawa N, Sakoda Y, Kida H.
  • Journal Title: Vet Microbiol Volume: 164 Pages: 39-45
  • Peer Reviewed
• [Journal Article] Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain. (2013)
  • Author(s): Okamatsu M, Sakoda Y, Hiono T, Yamamoto N, Kida H.
  • Journal Title: Virol J Volume: 10 Pages: 47
  • Peer Reviewed
• [Journal Article] Fluorescence polarization-based assay using N-glycan-conjugated quantum dots for screening in hemagglutinin blockers for influenza A viruses. (2013)
  • Author(s): Okamatsu M, Feng F, Ohyanagi T, Nagahori N, Someya K, Sakoda Y, Miura N, Nishimura S, Kida H.
  • Journal Title: J Virol Methods Volume: 187 Pages: 390-394
  • Peer Reviewed
• [Journal Article] The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks. (2013)
  • Author(s): Kajihara M, Sakoda Y, Soda K, Minari K, Okamatsu M, Takada A, Kida H.
  • Journal Title: Virol J Volume: 10 Pages: 45
  • Peer Reviewed
• [Journal Article] Purification of human and avian influenza viruses using cellulose sulfate ester (Cellufine Sulfate) in the process of vaccine production. (2012)
  • Author(s): Sakoda Y, Okamatsu M, Isoda N, Yamamoto N, Ozaki K, Umeda Y, Aoyama S, Kida H.
  • Journal Title: Microbiol Immunol Volume: 56 Pages: 490-495
  • Peer Reviewed
• [Journal Article] Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in 2010-2011 winter season in Japan. (2012)
  • Author(s): Sakoda Y, Ito H, Uchida Y, Okamatsu M, Yamamoto N, Soda K, Nomura N, Kuribayashi S, Shichinohe S, Sunden Y, Umemura T, Usui T, Ozaki H, Yamaguchi T, Murase T, Ito T, Saito T, Takada A, Kida H.
  • Journal Title: J Gen Virol Volume: 93 Pages: 541-550
  • Peer Reviewed
• [Journal Article] An H9N2 influenza virus vaccine prepared from a non-pathogenic isolate from a migratory duck confers protective immunity in mice against challenge with an H9N2 virus isolated from a girl in Hong Kong. (2012)
  • Author(s): Nomura N, Sakoda Y, Soda K, Okamatsu M,Kida H.
  • Journal Title: J Vet Med Sci Volume: 74 Pages: 441-447
  • Peer Reviewed
• [Journal Article] Characterization of avian influenza viruses isolated from domestic ducks in Vietnam in 2009 and 2010. (2012)
  • Author(s): Nomura N, Sakoda Y, Endo M, Yoshida H, Yamamoto N, Okamatsu M, Sakurai K, Hoang NV, Nguyen LV, Chu HD, Tien TN, Kida H.
  • Journal Title: Arch Virol Volume: 157 Pages: 247-257
  • Peer Reviewed
• [Journal Article] The nucleoprotein is responsible for intracerebral pathogenicity of A/duck/Mongolia/47/2001 (H7N1) in chicks. (2012)
  • Author(s): Isoda N, Tsuda Y, Asakura S, Okamatsu M, Sakoda Y, Kida H.
  • Journal Title: Arch Virol Volume: 12 Pages: 2257-2264
  • Peer Reviewed
• [Journal Article] Memory Immune Responses against Pandemic (H1N1) 2009 Influenza Virus Induced by a Whole Particle Vaccine in Cynomolgus Monkeys Carrying Mafa-A1*052ratio02. (2012)
  • Author(s): Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K.
  • Journal Title: PLoS One Volume: 7 Pages: 37220
  • Peer Reviewed
• [Journal Article] Evaluation of the reverse transcription loop-mediated isothermal amplification (RT-LAMP) as a screening method for the detection of influenza viruses in the fecal materials of water birds. (2011)
  • Author(s): Yoshida H, Sakoda Y, Endo M, Motoshima M, Yoshino F, Yamamoto N, Okamatsu M, Soejima T, Senba S, Kanda H, Kida H.
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 753-758
  • Peer Reviewed
• [Journal Article] Characterization of a non-pathogenic H5N1 influenza virus isolated from a migratory duck flying from Siberia in Hokkaido, Japan, in October 2009. (2011)
  • Author(s): Yamamoto N, Sakoda Y, Motoshima M, Yoshino F, Soda K, Okamatsu M, Kida H.
  • Journal Title: Virol J Volume: 8 Pages: 65
  • Peer Reviewed
• [Journal Article] Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009. (2011)
  • Author(s): Uchida Y, Kanehira K, Mase M, Takemae N, Watanabe C, Usui T, Fujimoto Y, Ito T, Igarashi M, Ito K, Takada A, Sakoda Y, Okamatsu M, Yamamoto Y, Nakamura K, Kida H, Hiromoto Y, Tsuda T, Saito T.
  • Journal Title: Vet Microbiol Volume: 147 Pages: 1-10
  • Peer Reviewed
• [Journal Article] A low pathogenic H5N2 influenza virus isolated in Taiwan acquired high pathogenicity by consecutive passages in chickens. (2011)
  • Author(s): Soda K, Cheng MC, Yoshida H, Endo M, Lee SH, Okamatsu M, Sakoda Y, Wang CH, Kida H.
  • Journal Title: J Vet Med Sci Volume: 73 Pages: 767-772
  • Peer Reviewed
• [Journal Article] H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens. (2011)
  • Author(s): Soda K, Asakura S, Okamatsu M, Sakoda Y, Kida H.
  • Journal Title: Virol J Volume: 8 Pages: 64
  • Peer Reviewed
• [Journal Article] Virological surveillance and phylogenetic analysis of the PB2 genes of influenza viruses isolated from wild water birds flying from their nesting lakes in Siberia to Hokkaido,Japan in autumn (2011)
  • Author(s): Samad RAS, Y. Tsuda, Y. Simulundu, EManzoor, R.Okamatsu, M.Ito, K.Kida, H.
  • Journal Title: Jpn J Vet Res Volume: 59 Pages: 15-22
  • Peer Reviewed
• [Journal Article] A vaccine prepared from a non-pathogenic H5N1 influenza virus strain from the influenza virus library conferred protective immunity to chickens against the challenge with antigenically drifted highly pathogenic avian influenza virus. (2011)
  • Author(s): Samad RA, Nomura N, Tsuda Y, Manzoor R, Kajihara M, Tomabechi D, Sasaki T, Kokumai N, Ohgitani T, Okamatsu M, Takada A, Sakoda Y, Kida H.
  • Journal Title: Jpn J Vet Res Volume: 59 Pages: 23-29
  • Peer Reviewed
• [Journal Article] Antigenic and genetic analysis of H3N8 influenza viruses isolated from horses in Japan and Mongolia, and imported from Canada and Belgium during 2007-2010. (2011)
  • Author(s): Motoshima M, Okamatsu M, Asakura S, Kuribayashi S, Sengee S, Batchuluun D, Ito M, Maeda Y, Eto M, Sakoda Y, Sodnomdarjaa R, Kida H.
  • Journal Title: Arch Virol Volume: 156 Pages: 1379-1385
  • Peer Reviewed
• [Journal Article] An H5N1 highly pathogenic avian influenza virus that invaded Japan through waterfowl migration. (2011)
  • Author(s): Kajihara M, Matsuno K, Simulundu E, Muramatsu M, Noyori O, Manzoor R, Nakayama E, Igarashi M, Tomabechi D, Yoshida R, Okamatsu M, Sakoda Y, Ito K, Kida H, Takada A.
  • Journal Title: Jpn J Vet Res Volume: 59 Pages: 89-100
  • Peer Reviewed
• [Journal Article] Improvement of the H5N1 influenza virus vaccine strain to decrease thepathogenicity in chicken embryos. (2011)
  • Author(s): Isoda N, Sakoda Y, Okamatsu M, Tsuda Y, Kida H.
  • Journal Title: Arch Virol Volume: 156 Pages: 557-563
  • Peer Reviewed
• [Presentation] 2011年に日本で野鳥から分離されたH5N1高病原性鳥インフルエンザウイルスのカラス、スズメおよびクマネズミに対する病原性 (2012)
  • Author(s): 岡松正敏、迫田義博、本橋友里恵、山本直樹、栗林沙弥、市川貴也、谷川力、喜田宏
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪、大阪市
  • Year and Date: 20121113-15
• [Presentation] 非病原性鳥インフルエンザウイルス A/duck/Hokkaido/Vac-1/2004 (H5N1) のニワトリに対する病原性獲得に与るウイルス因子の同定 (2012)
  • Author(s): 山本直樹、迫田義博、曽田公輔、岡松正敏、喜田宏
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪、大阪市
  • Year and Date: 20121113-15
• [Presentation] 鳥インフルエンザウイルスがブタに感染するとSAα2,6Galレセプターを認識するウイルスが選択される (2012)
  • Author(s): 七戸新太郎、岡松正敏、迫田義博、喜田宏
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: グランキューブ大阪、大阪市
  • Year and Date: 20121113-15
• [Presentation] 2011年に日本で野鳥から分離されたH5N1高病原性鳥インフルエンザウイルスのカラス、スズメおよびクマネズミに対する病原性 (2012)
  • Author(s): 岡松正敏、迫田義博、本橋友里恵、山本直樹、栗林沙弥、喜田宏
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学、盛岡市
  • Year and Date: 20120914-16
• [Presentation] 2010-2012年に日本で野鳥から分離されたH5N1高病原性鳥インフルエンザウイルス (2011)
  • Author(s): 岡松正敏、伊藤啓史、内田裕子、迫田義博、山本直樹、曽田公輔、笛吹達史、尾崎弘一、山口剛士、村瀬敏之、高田礼人、伊藤壽啓、西藤岳彦、喜田宏
  • Organizer: 第152回日本獣医学会学術 集会
  • Place of Presentation: 大阪府立大 学、大阪
  • Year and Date: 20110919-21
• [Presentation] H5N1非病原性鳥インフルエンザウイルスを用いて試製したワクチンの異なる系統のウイルス攻撃に対する効果 (2011)
  • Author(s): 七戸新太郎、岡松正敏、山本直樹、野田優、野元由佳、瀧川義康、迫田義博、喜田宏
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学、大阪
  • Year and Date: 20110919-21
• [Presentation] カモの非病原性インフルエンザウイルスがニワトリに感染し増殖する条件 (2011)
  • Author(s): 日尾野隆大、岡松正敏、迫田義博、喜田宏
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学、大阪
  • Year and Date: 20110919-21
• [Presentation] Comparison of potency of whole virus particle and ether split pandemic influenza vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) (2011)
  • Author(s): M. Okamatsu, Y. Sakoda, T. Hiono, N. Yamamoto, H. Kida.
  • Organizer: 国際微生物学連合2011会議
  • Place of Presentation: 札幌コンベンションセンター、札幌市
  • Year and Date: 2011-09-15
• [Presentation] Potency of an inactivated avian influenza vaccine prepared from a non-pathogenic H5N1 virus against the challenge with an antigenically drifted virus of clade 2.3.4 (2011)
  • Author(s): S. Shichinohe, Y. Sakoda, N. Yamamoto, M. Okamatsu, Y. Noda, Y. Nomoto, T. Honda, Y. Takigawa, H. Kida.
  • Organizer: 国際微生物学連合2011会議
  • Place of Presentation: 札幌コンベンションセンター、札幌市
  • Year and Date: 2011-09-15
• [Remarks]
  • URL: http://www.vetmed.hokudai.ac.jp/organization/microbiol/index.html