2012 Fiscal Year Final Research Report
Experimental study on induction of anti-virus antibody producing cells into the brain
Project/Area Number |
23780306
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied veterinary science
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Research Institution | Hokkaido University |
Principal Investigator |
SUNDEN Yuji 北海道大学, 大学院・獣医学研究科, 助教 (20451403)
|
Project Period (FY) |
2011 – 2012
|
Keywords | 病理学 / 抗体 / ウイルス / 中枢神経系 / 神経細胞 / ケモカイン / 人獣共通感染症 |
Research Abstract |
The objective of the present study is to establish an effective prophylactic/therapeutic measure against neurotropic virus infections, rabies and/or pseudorabies. By using experimental animals, an induction of anti-virus antibody producing cells from peripheral tissues into central nervous system (CNS) was tested. It is demonstrated that an induction of antibody-secreting cells into the CNS is partly mediated by chemokine CXCL12 expression. Further, the induction of anti-virus antibodies into CNS is effective for inhibition of virus propagation, especially for rabies virus, in mice experiment.
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Research Products
(9 results)