Experimental study on induction of anti-virus antibody producing cells into the brain

2012 Fiscal Year Final Research Report

• Project/Area Number: 23780306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: SUNDEN Yuji 北海道大学, 大学院・獣医学研究科, 助教 (20451403)
• Project Period (FY): 2011 – 2012
• Keywords: 病理学 / 抗体 / ウイルス / 中枢神経系 / 神経細胞 / ケモカイン / 人獣共通感染症

Research Abstract

The objective of the present study is to establish an effective prophylactic/therapeutic measure against neurotropic virus infections, rabies and/or pseudorabies. By using experimental animals, an induction of anti-virus antibody producing cells from peripheral tissues into central nervous system (CNS) was tested. It is demonstrated that an induction of antibody-secreting cells into the CNS is partly mediated by chemokine CXCL12 expression. Further, the induction of anti-virus antibodies into CNS is effective for inhibition of virus propagation, especially for rabies virus, in mice experiment.

Research Products

• [Journal Article] CXCL12 improves immune responses to neurotropic virus propagation in the CNS by attracting antibody secreting cells. (2012)
  • Author(s): Lee H, Sunden Y, Sakai Y, Ochiai K, Umemura T.
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 150 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Experimental intracerebral vaccination protects mouse from a neurotropic virus by attracting antibody secreting cells to the CNS. (2011)
  • Author(s): Lee H, Sunden Y, Ochiai K, Umemura T
  • Journal Title: Immunology Letters Volume: 139 Pages: 102-109
  • Peer Reviewed
• [Presentation] 抗体による狂犬病ウイルス感染細胞からのウイルス排除効果 (2013)
  • Author(s): 中嶋七瀬
  • Organizer: 第155回日本獣医学会学術集会
  • Place of Presentation: 東京大学駒場キャンパス、東京都目黒区
  • Year and Date: 2013-03-30
• [Presentation] マウスを用いたウリジン三リン酸(UTP)の抗狂犬病ウイルス抗体産生増強効果 (2013)
  • Author(s): 岩木芳美
  • Organizer: 第155回日本獣医学会学術集会
  • Place of Presentation: 東京大学駒場キャンパス、東京都目黒区
  • Year and Date: 2013-03-30
• [Presentation] Chemokines improveanti-neurotropic virus immune response by attracting antibody secreting cells to the CNS (2011)
  • Author(s): H Lee
  • Organizer: The 62ndAnnual Meeting of the American College of Veterinary Pathologists and the46th Annual Meeting of the American Society of Veterinary Clinical Pathology
  • Place of Presentation: Nashville, Tennessee, Nashville Convention Center, USA
  • Year and Date: 2011-12-04
• [Presentation] Chemokine improved anti-neurotropic virus immune response by attracting antibody secreting cells to the CNS (2011)
  • Author(s): 李賢敬
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学、大阪府堺市
  • Year and Date: 2011-09-20
• [Presentation] Chemokine improvedanti-neurotropic virus immune response by attracting antibody secreting cells to the CNS (2011)
  • Author(s): H Lee
  • Organizer: The 3^rd Inernational Young Reseacher Seminar for Zoonosis Control
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2011-09-17
• [Presentation] Possible origin of CSF antibodies induced by intrathecal immunization and apply to rabies control in experimental animals (2011)
  • Author(s): Y Sunden
  • Organizer: The 3^rd Inernational Young ReseacherSeminar for Zoonosis Control
  • Place of Presentation: Hokkaido University, Sapporo,Japan
  • Year and Date: 2011-09-17
• [Presentation] Origin of CSF antibodies induced by intrathecal immunization and apply to rabies control in experimental animals (2011)
  • Author(s): Y Sunden
  • Organizer: 29^th meeting of the European society of veterinary pathology & The European college of veterinary pathologist
  • Place of Presentation: Ultuna campus of Swedish University of Agricultural Sciences, Uppsala, Sweden
  • Year and Date: 2011-09-09