2012 Fiscal Year Final Research Report
Control of regular structure and functionalization of oligomers of bicyclic beta-proline derivative
| Project/Area Number |
23790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTANI Yuko 東京大学, 大学院・薬学系研究科, 助教 (60451853)
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| Project Period (FY) |
2011 – 2012
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| Keywords | オリゴマー / シス-トランス異性化 / NMR / 三級アミド / 分子動力学計算 / 規則 構造 / 二環性骨格 / 分子の架橋化 |
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| Research Abstract |
Methods for synthesis of conformationally constrained β-proline mimics, that is, bridgehead-substituted7-azabicyclo[2.2.1]heptane-2-endo-carboxylic acids was established. The oligomers take ordered structure with trans-amide bonds in solution. And cis-trans equilibrium of the cis-amide-type bicyclic dimer substituted at the bridgehead position is controlled dynamically by cross-linking reaction.
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