2012 Fiscal Year Final Research Report
Regiocontrol of heteroaryne reactions by redox change
| Project/Area Number |
23790017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IKAWA Takashi 静岡県立大学, 薬学部, 助教 (20453061)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ピリダイン / イソキノリン / Diels-Alder 反応 / 位置選択性 / ケイ素官能基 / フラン / 複素環 / カップリング |
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| Research Abstract |
A new synthetic route to isoquinoline derivatives consisting regioselective Diels-Alder reactions of 3,4-pyridynes with furans and following functional group transformations is reported. The key for the regioselectivity of the cycloaddition reactions is electropositive silicon atom of the 2-position of 3,4-pyridyne. This directing group can also be substituted with various functional groups.
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Research Products
(18 results)
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[Journal Article] Generation of 3-Borylbenzynes, Their Regioselective Diels-Alder Reactions, and Theoretical Analysis2013
Author(s)
Takagi Akira, Ikawa Takashi, Kurita Yurio, Saito Kozumo, Azechi Kenji, Egi Masahiro, Itoh Yuji, Tokiwa Hiroaki, Kita Yasuyuki, Akai Shuji
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Journal Title
Tetrahedron
Volume: 69
Pages: 4338-4352
DOI
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[Journal Article] ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2-Silylanilines2011
Author(s)
Ikawa Takashi, Nishiyama Tsuyoshi, Shigeta Takashi, Mohri Shinya, Morita Shinsuke, Takayanagi Sho-ichi, Terauchi Yuki, Morikawa Yuki, Takagi Akira, Ishikawa Yoshinobu, Fujii Satoshi, Kita Yasuyuki, Akai Shuji
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Journal Title
Angew. Chem. Int. Ed
Volume: 50
Pages: 5674
DOI
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