2014 Fiscal Year Final Research Report
Synthesis and application of asterolaurins having anti-cancer activity
| Project/Area Number |
23790018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | 抗がん活性物質 / 抗HIV活性物質 / アステロラウリン類 / キセニカン骨格 / 環拡大反応 |
|---|
| Outline of Final Research Achievements |
Synthesis of the xenialactol-methylacetal core and the unsaturated fatty acid side chain of 9-deoxyxenialactol C (asterolaurins analogue) were achieved. The synthetic method involved the following key step: i) [1,3]-sigmatropic rearrangement, ii) isomerization of nitrile and iii) acid-induced domino deprotection/lactol cyclization/methylacetalization in one step.
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| Free Research Field |
有機合成化学
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