2012 Fiscal Year Final Research Report
Total synthesis of biologically active compounds by using asymmetricorganocatalytic reactions
| Project/Area Number |
23790024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ISHIKAWA Hayato 熊本大学, 大学院・自然科学研究科, 准教授 (80453827)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 有機合成化学 / ドミノ反応 / ワンポット合成 / マイクロフロー合成 |
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| Research Abstract |
Efficient total synthesis of Anti-Influenza drug oseltamivir knownas Tamiflu was accomplished. The key process of the synthesis for applied to the industrialscale, is our originally developed asymmetric organocatalytic reactions, domino reaction,one-pot process and micro-flow reactions. In addition, efficient synthetic methods forsynthesis of zanamivir known as Relenza were discovered.
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