2012 Fiscal Year Final Research Report
The role of TYK2 in innate and acquired immune system
| Project/Area Number |
23790067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
MUROMOTO Ryuta 北海道大学, 大学院・薬学研究院, 助教 (30455597)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 免疫学 / 炎症 / サイトカイン |
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| Research Abstract |
In this study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad thickness, imiquimod-induced psoriasis-like skin inflammation, and dextran sulfate sodium-induced colitis. In these disease models, Tyk2 deficiency influenced the phenotypes in immunity and/or inflammation.
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[Journal Article] Kruppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions amongSTAT3, p300, and NF-κB/p652011
Author(s)
Kamitani S, Togi S, Ikeda O, Nakasuji M, Sakauchi A, Sekine Y, Muromoto R, Oritani K, Matsuda T
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Journal Title
J Immunol
Volume: 187(5)
Pages: 2476-83
DOI
Peer Reviewed
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