2012 Fiscal Year Final Research Report
Scaffolding structure in functional calcium microdomainin vascular smooth muscles
| Project/Area Number |
23790092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAMAMURA Hisao 名古屋市立大学, 大学院・薬学研究科, 准教授 (80398362)
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| Research Collaborator |
IMAIZUMI Yuji 名古屋市立大学, 大学院・薬学研究科, 教授 (60117794)
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| Project Period (FY) |
2011 – 2012
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| Keywords | カルシウム動態 / マイクロドメイン / 血管 / 全反射蛍光顕微鏡 / カリウムチャネル / カベオラ / アクチン / 平滑筋 |
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| Research Abstract |
To clarify the molecular dynamics of large conductancecalcium-activated potassium channels in the functional calcium microdomain, we examined the single-molecule imaging using total internal reflection fluorescence microscopy. These results indicate that the molecular dynamics are strongly restricted by cytoskeleton and direct interaction with caveolin in vascular smooth muscle cells.
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[Journal Article] Dihydropyridine Ca^<2+>channel blockers increase cytosolic [Ca^<2+>] by activating Ca^<2+>-sensing receptors in pulmonary arterial smooth muscle cells.2013
Author(s)
Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wan J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX.
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Journal Title
Circ Res
Volume: 112
Pages: 640-50
Peer Reviewed
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[Journal Article] Enhanced Ca^<2+>-sensing receptor function in idiopathic pulmonary arterial hypertension2012
Author(s)
Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX
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Journal Title
Circ Res,Circ Res
Volume: 111
Pages: 469-81
Peer Reviewed
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[Journal Article] TRIC-A channels in vascular smooth muscle contribute to blood pressure maintenance2011
Author(s)
Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T, Ta
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Journal Title
Cell Metab
Volume: 14
Pages: 231-41
Peer Reviewed
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[Journal Article] Functional characterization of voltage-dependent Ca^2+channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS
Author(s)
Ko EA, Wan J, Yamamura A, Zimnicka AM, Yamamura H, Yoo HY, Tang H, Smith KA, Sundivakkam PC, Zeifman A, Ayon RJ, Makino A, Yuan JX.
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Journal Title
Am J Physiol Cell Physiol
Volume: (in press)
DOI
Peer Reviewed
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