2013 Fiscal Year Final Research Report
Development of the experimentalmethod to inhibitthe tumor invasion by targeting a cellmigration factor, ZF21 protein
Project/Area Number |
23790109
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
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Research Institution | Setsunan University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Keywords | 細胞生物学 / 癌細胞の浸潤抑制 |
Research Abstract |
ZF21 protein promotes the cellular migration and tumor invasion via promoting the turnover of the adhesion structures at the contact sites between cell and extracellular matrix through interacting with focal adhesion kinase(EAK). In this study, I elucidated that the overexpression of the N-terminal fragment of ZF21 protein, which includes the EAK・interacting region, suppresses the tumor cell migration via inhibition ofthe interaction between ZF21 and FAK.
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