2012 Fiscal Year Final Research Report
Structure-activity relationship of atpenin A5 derivatives as complex II selective inhibitors
| Project/Area Number |
23790140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 構造活性相関 / complex II / 天然有機化合物 |
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| Research Abstract |
Structure-activity relationship of atpenin A5 focused on 2-position and substituents of the side chain has been achieved. On this study, the importance of stereochemistry and the presence of each methyl and chloro groups on the side chain were elucidated.
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