2012 Fiscal Year Final Research Report
Development of test for central nervous system developmental toxicity using in vitro organization from human pluripotent stem cells.
| Project/Area Number |
23790150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo Medical University (2012)
The University of Tokyo (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 発生毒性 / 多能性幹細胞 |
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| Research Abstract |
The most important point is the regulation of uniformity of differentiation in establishment the test developmental toxicity using pluripotent stem cells. In this study, the timing and efficiency of nervous differentiation from mouse ES cell were successfully made uniform. The central nervous system developmental toxicityof chemical can be detected in the system. Additionally, shortening of period for neural differentiation was achieved by the modification of culture condition of human ES cells.
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