Development of shield-arms typed oligonucleotides for cancer therapy

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790202
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: FUJIWARA Naruyoshi 聖マリアンナ医科大学, 医学部, 助教 (50365425)
• Project Period (FY): 2011 – 2012
• Keywords: 医療薬剤学 / ドラッグデリバリーシステム / ナノドラッグ

Research Abstract

In this study, I showed that the shield-arms type oligonucleotide was able to down-regulate VEGF expression dependent on TGF-〓 in macrophage and induce anti-tumor effect by enhancement of IRF-1 expression in macrophage residing the tumor environment. It is suggested that this oligonucleotide will become new strategy of anti-angiogenesis by suppression of cancer as shields and activation for macrophages asarms.

Research Products

• [Presentation] 癌治療を目的としたシールドアームズ型遺伝子製剤の開発 (2012)
  • Author(s): 藤原成芳
  • Organizer: 日本薬学会第132 年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Patent(Industrial Property Rights)] Method of delivering agent into target cell (2011)
  • Inventor(s): HAGA, Makoto; (JP).FUJIWARA, Naruyoshi; (JP).NISHI, Akihiro; (JP).KUBO, Satoru; (JP).KUSHIBIKI, Takanori; (JP)
  • Industrial Property Rights Holder: HAGA, Makoto [JP/JP]; (JP) (For US Only).FUJIWARA, Naruyoshi [JP/JP]; (JP) (For US Only).NISHI, Akihiro [JP/JP]; (JP) (For US Only).KUBO, Satoru [JP/JP]; (JP) (For US Only).KUSHIBIKI, Takanori[JP/JP]; (JP) (For US Only)
  • Industrial Property Number: PCT patent Pub. NO.: WO2011052804International Application No.: PCT/JP2010/069767
  • Filing Date: 20110500
  • Overseas