2012 Fiscal Year Final Research Report
Determination of differential UGT expression in brain region and prediction of drug interaction via UGT
| Project/Area Number |
23790207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
KATOH Miki 名城大学, 薬学部, 准教授 (70345594)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳 / グルクロン酸抱合 / UGT1a / mRNA / 誘導 |
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| Research Abstract |
All UGT1A isoforms and UGT1A enzyme activities were detected in 9 regions of the rat brain. We showed that phenobarbital treatment induced UGT1A1, UGT1A6, and UGT1A7 mRNA expression and enzyme activities in some regions of the rat brain.
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