The molecular basis of the Blood-Brain Barrier

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790236
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Keio University
• Principal Investigator: KANDA Hiroshi 慶應義塾大学, 医学部, 助教 (60508597)
• Project Period (FY): 2011 – 2012
• Keywords: 血液脳関門 / BBB / ショウジョウバエ / 遺伝学 / グリア

Research Abstract

In order to address the molecular mechanismsfor regulating the integrity of Blood-Brain Barrier (BBB), we have utilized the Drosophila melanogaster, fruit fly, as a model system. We have performed an RNAi-based screen to identify genes that are involved i

Research Products

• [Journal Article] The Drosophila ortholog of MLL 3/MLL 4, trithorax related, functions as a negative regulator of tissue growth (2013)
  • Author(s): Kanda H, Nguyen A, Chen L, Okano H and Hariharan I
  • Journal Title: Mol. Cell Biol. Volume: 33 Pages: 1702-1710
  • Peer Reviewed
• [Journal Article] Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death (2011)
  • Author(s): Kanda H, Igaki T, Okano H, Miura M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108 Pages: 18977-82
  • Peer Reviewed
• [Presentation] MLL family proteins differently regulate cell growth and proliferation in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Alexander Nguyen, Hideyuki Okano and Iswar Hariharan.
  • Organizer: 第35回日本分子生物学会年会:ポスター発表
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡)
  • Year and Date: 20121211-14
• [Presentation] Identification of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: Neuro-Vascular Wiring Symposium 2012:ポスター発表
  • Place of Presentation: 奈良県新公会堂(奈良)
  • Year and Date: 20121112-13
• [Presentation] RNAi-based genetic screen of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 第10回日本ショウジョウバエ研究会、口頭発表
  • Place of Presentation: 東京慈恵会医科大学(東京)
  • Year and Date: 20121013-15
• [Presentation] A genetic approach for the organization and function of the Blood-Brain Barrier in Drosophila (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: The 4th Biennial Symposium on Brain and Mind Research in the Asia-Pacific (BMAP 2012):ポスター発表
  • Place of Presentation: 慶應義塾大学三田キャンパス(東京)
  • Year and Date: 20120829-31
• [Presentation] Conserved metabolic energy production pathways govern Eiger/TNF-induced non-apoptotic cell death (2011)
  • Author(s): Hiroshi Kanda, Tatsuhi Igaki, Hideyuki Okano, and Masayuki Miura
  • Organizer: 第34回日本分子生物学会年会:ポスター発表
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 20111213-16
• [Presentation] Molecular Basis of the integrity of Blood-Brain Barrier in Drosophila (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 第34回日本神経科学大会、口頭発表
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 20110914-17
• [Presentation] A Genetic Approach for the Organization and Function of the Blood-Brain Barrier in Drosophila (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano.
  • Organizer: The 1st Asia Pacific Drosophila Research Conference:ポスター発表
  • Place of Presentation: Chientan Youth Activity Center(台湾・台北)
  • Year and Date: 20110522-25
• [Remarks] 慶應義塾大学 医学部 生理学教室
  • URL: http://www.okano-lab.com/