2012 Fiscal Year Final Research Report
The effect of HA4 against hypoxic-ischemic brain injury
| Project/Area Number |
23790239
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 低酸素 / 脳虚血 / 神経細胞死 / ヒアルロン酸4糖 / Toll 様受容体 / 炎症性サイトカイン / 海馬 |
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| Research Abstract |
I found that hyaluronan tetrasaccharide (HA4)-treated mice rescued the hippocampal pyramidal neurons 24hours after H-I injury, and that the protective effect of neurons by HA4 reduced expression of inflammatory cytokines related to the inactivation of NF・B.Both in vivo and in vitro data suggested that the reduced expression of inflammatory cytokines was due to the agonistic effect of HA4 against the Toll-like receptor 2.
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Research Products
(5 results)
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[Journal Article] Purified mesenchymal stem cells are an efficient source for iPS cell induction.2011
Author(s)
Niibe K, Kawamura Y, Araki D, Morikawa S, Miura K, Suzuki S, Shimmura S, Sunabori T, Mabuchi Y, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y.
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Journal Title
PLOS One
Volume: 6巻3号
Pages: e17610
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