2012 Fiscal Year Final Research Report
The mechanism of circadian clock in the subparaventricular zone by the suprachiasmatic nucleus
| Project/Area Number |
23790277
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 生体リズ |
|---|
| Research Abstract |
The suprachiasmatic nucleus (SCN) is the circadian center and subparaventricular zone (SPvZ) is the primary relay point of the circadian rhythm delivered from the SCN. Using mPer2promoter::Luciferase knock-in mice, we have found that SPvZ in the cultured brain slice containing SCN generated the bioluminescence rhythm antiphasic to that of the SCN. When SPvZ were culture alone, the bioluminescence rhythm in the SPvZ attenuated immediately, however, afterward co-culture with SCN recovered the rhythm of SPvZ. Now we are utilizing this system and found some requisites to keep the circadian bioluminescence rhythm in the SPvZ.
|
