2012 Fiscal Year Final Research Report
Investigation of the sex-specific rearing conditions to develop adaptive emotionality and sociability
| Project/Area Number |
23790279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 統合失調症 / 性差 / 動物モデル |
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| Research Abstract |
We found that maternal deprivation in the middle of a stress hyporesponsive period (SHRP) increased a type of anxiety-related behaviour and decreased social behaviour in male rats. Since numerous studies have provided evidence that maternal deprivation in the middle of a SHRP causes multiple behavioural and physiological abnormalities that mimic positive symptoms of schizophrenia in humans, an interpretation of our results and previous studies in the context of the neurodevelopmental hypothesis of schizophrenia suggests that maternal deprivation in the middle of the SHRP in rats models some positive and negative aspects of schizophrenia. To investigate the neurochemical characteristics of rats that experience maternal deprivation in the middle of the SHRP in the context of a possible animal model of the symptoms of schizophrenia, we examined calcineurin expression in the hippocampus of maternally deprived rats and found the decreased calcineurin expression in the maternally deprived male rats
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