2013 Fiscal Year Final Research Report
To reveal a cause of development of hypertension with long term measurement of sympathetic nerve activity
| Project/Area Number |
23790285
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
YOSHIMOTO Misa 独立行政法人国立循環器病研究センター, 研究所, 研究員 (20418784)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 高血圧 / 神経性動脈圧調節 / 腎交感神経活動 / 腰部交感神経活動 / ラット |
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| Research Abstract |
Hypertension is a disease. One in four adults in the world have been diagnosed with high blood pressure. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. Salt sensitive hypersensitive rats and stroke-prone spontaneously hypertensive rats were used this experiments. The rats were chronically instrumented with a bipolar electrode for measurements of renal (RSNA) and lumbar sympathetic nerve activity (LSNA) and telemeter for measurements of arterial pressure (AP) and heart rate (HR). RSNA and LSNA apparently did not increase while development of hypertension occurred. It is therefor likely that possible contribution of sympathetic nerve activity to the initial development of hypertension in those hypersensitive rats remains uncertain.
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