2012 Fiscal Year Final Research Report

Analysis of upstream and downstream signaling of IFITM3

Research Project

Project/Area Number	23790290
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General pharmacology
Research Institution	Nagoya University
Principal Investigator	NAKAJIMA Akira 名古屋大学, 医学系研究科, 講師 (20419237)
Project Period (FY)	2011 – 2012
Keywords	IFITM3 / 神経発達障害 / サイトカイン / 統合失調症 / アストログリア
Research Abstract	Treatment with IFN-β、IL-1β, or TNF-α dose-dependently induced IFITM3 gene expression in cultured astrocytes. Pretreatment with helenalin,an NFκB inhibitor, had no effect on PolyI:C-induced IFITM3 gene epression. In contrast, PolyI:C-induced IFITM3 gene expression was significantly inhibited by pretreatment with BX795, a TBK-1 inhibitor. These results suggest that PolyI:C induces IFITM3 gene expression through TBK-1-IRF3 pathway in cultured astrocytes.