2012 Fiscal Year Final Research Report
The effect of antidepressant on Fibroblast growth factor (FGF) receptor, as a novel therapeutic target for major depression.
| Project/Area Number |
23790297
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Hiroshima University |
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Principal Investigator |
NAKASHIMA Kazue (HISAOKA Kazue) 広島大学, 大学院・医歯薬保健学研究院, 助教 (20393431)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 抗うつ薬 / グリア |
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| Research Abstract |
In this study, I examined the effect of amitriptyline (a tricyclic antidepressant) on the Fibroblast growth factor (FGF) receptor in glia. I reported that the amitriptyline-induced FGF receptor activation is occurred by FGF-2 shedding through matrix metalloproteinase activation (Hisaoka K et al., J Biol Chem 286(24): 21118-21128, 2011).
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Research Products
(17 results)
