2012 Fiscal Year Final Research Report
the role of renal tubular p21 in diabetic nephropathy
| Project/Area Number |
23790299
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腎臓 |
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| Research Abstract |
We examined the role of renal senescence in the diabetic kidney. The animal models of diabetes (either type 1 or 2) showed early-onset and time-dependently increased renal senescence through p21-dependent pathway in proximal tubular cells. The senescent diabetic kidney had an increase in TNF-α and immune cells infiltration. The treatment of diabetes reversed the senescent kidney into normal. The results suggest that renal senescence is treatable and could be a new target of diabetic nephropathy.
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