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2013 Fiscal Year Final Research Report

Functional analysis of key molecule of breast cancer stem cells

Research Project

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Project/Area Number 23790357
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

HINOHARA Kunihiko  東京大学, 医科学研究所, 特任助教 (50549467)

Project Period (FY) 2011 – 2013
Keywordsbreast cancer / cancer stem cells / HRG / ErbB / PI3K / IGF
Research Abstract

We identified HRG/ErbB signaling as a key molecular mechanism on regulating breast cancer stem cell properties. ErbB signaling maintains breast cancer stem cell properties via PI3K/NF-kappaB pathway, suggesting that crosstalk between growth factor signaling and inflammatory response pathway is important for such regulation. Moreover, IGF2 signaling is required for maintenance of the breast cancer stem cell properties as a downstream mediator of PI3K signaling. Also, HRG signature and IGF signature identified by microarray analysis is strongly associated with both breast cancer grade and prognosis such as metastasis or relapse. These observations suggest that these growth factor signaling have important roles on malignant progression of breast cancer through maintenance of breast cancer stem cell properties.

  • Research Products

    (16 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) Presentation (10 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma2014

    • Author(s)
      Kohsaka S, Hinohar a K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S
    • Journal Title

      Neuro Oncol

      Volume: (Epub ahead of print)

  • [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013

    • Author(s)
      Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohar a K, Gotoh N, Suzuki S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432(1) Pages: 175-181

  • [Journal Article] Effect of in vivo administration of reprogramming factors in the mouse liver2013

    • Author(s)
      Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohar a K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Doki Y, Mori M, Ishii H, Nagano H
    • Journal Title

      Oncol Lett

      Volume: 6(2) Pages: 323-328

  • [Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012

    • Author(s)
      Hinohar a K, Kobayashi S, Kanauchi H, Shimizu S, Nishioka K, Tsuji E, Tada K, Umezawa K, Mori M, Ogawa T, Inoue J, Tojo A, Gotoh N
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Pages: 6584-6589

  • [Presentation] Insulin-like growth factor signaling regulates breast cancer stem cell properties2013

    • Author(s)
      Hinohara K, Shimamura T, Kanauchi H, Niida A, Tuji E, Nishioka K, Tada K, Mori M, Ogawa T, Miyano S, Tojo A, Gotoh N
    • Organizer
      The 36th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Japan
    • Year and Date
      20131200
  • [Presentation] Insulin-like growth factor signaling regulates breast cancer stem cell properties2013

    • Author(s)
      Hinohara K, Shimamura T, Kanauchi H, Niida A, Tuji E, Nishioka K, Tada K, Mori M, Ogawa T, Miyano S, Tojo A, Gotoh N
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Japan
    • Year and Date
      20131000
  • [Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2013

    • Author(s)
      Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Tada K, Ogawa T, Miyano S, Gotoh N
    • Organizer
      The 11th Stem Cell Research Symposium
    • Place of Presentation
      Japan
    • Year and Date
      20130500
  • [Presentation] ErbB signaling regulates the mammosphere formation of breast cancer2013

    • Author(s)
      Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Tada K, Ogawa T, Miyano S, Gotoh N
    • Organizer
      The 10th Japan Research Association For Immunotherapeutics
    • Place of Presentation
      Japan
    • Year and Date
      20130200
  • [Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012

    • Author(s)
      Hinohara K, Shimamura T, Fukuda H, Tominaga K, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Tada K, Ogawa T, Miyano S, Gotoh N
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Japan
    • Year and Date
      20121200
  • [Presentation] A PI3K-dependent gene expression program that regulates mammosphere formation of breast cancer cells2012

    • Author(s)
      Hinohara K, Shimamura T, Kanauchi H, Niida A, Yamaguchi R, Imoto S, Ogawa T, Miyano S, Gotoh N
    • Organizer
      The 71nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Japan
    • Year and Date
      20120900
  • [Presentation] ErbB/NF-κB signaling controls self-renewal of breast cancer stem cells2011

    • Author(s)
      Hinohara K, Kobayashi S, Umezawa K, Masaki Mori, Kanauchi H, Ogawa T, Inoue J, Tojo A, Gotoh N
    • Organizer
      The 34th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Japan
    • Year and Date
      20111200
  • [Presentation] Heregulin-β1/ErbB signaling regulates self-renewal of breast cancer stem cells through activation of NF-κB2011

    • Author(s)
      Hinohara K, Kobayashi S, Umezawa K, Tojo A, Inoue J, Masaki Mori, Kanauchi H, Ogawa T, Gotoh N
    • Organizer
      The 70nd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Japan
    • Year and Date
      20111000
  • [Presentation] EGF receptor/ErbB-NFκB signaling for self-renewal of breast cancer stem cells2011

    • Author(s)
      Hinohara K, Kobayashi S, Umezawa K, Tojo A, Inoue J, Kanauchi H, Ogawa T, Gotoh N
    • Organizer
      The 9th Stem Cell Research Symposium
    • Place of Presentation
      Japan
    • Year and Date
      20110500
  • [Presentation] ErbB/NF-κB signaling controls mammosphere formation in human breast cancer2011

    • Author(s)
      Hinohara K, Kobayashi S, Kanauchi H, Umezawa K, Masaki Mori, Ogawa T, Inoue J, Tojo A, Gotoh N
    • Organizer
      The 10th Stem Cell Research Symposium
    • Place of Presentation
      Japan
    • Year and Date
      20110500
  • [Book] 受容体型チロシンキナーゼErbBと転写因子NF-κBによる乳がん幹細胞維持の分子機構実験医学Vol.30 No.14 (9月号)2012

    • Author(s)
      日野原邦彦、後藤典子
    • Total Pages
      2272-2275
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/system-seimei/index.htm

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Published: 2015-06-25  

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