2013 Fiscal Year Final Research Report
Clinicopathologic features of gastric cancer associated with liver metastasis
| Project/Area Number |
23790390
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
USHIKU Tetsuo 東京大学, 医学部附属病院, 助教 (60376415)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 胃癌 / 肝転移 |
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| Research Abstract |
This project demonstrated that embryonic stem cell markers, such as SALL4 and Claudin-6, were specifically expressed in a subset of gastric cancer which is highly associated with liver metastasis. This subset of gastric cancer showed relatively high frequency of HER2 positivity as well. Finally, we clarified the clinicopathologic features of very well differentiated gastric carcinoma with intestinal type, which is unlikely to develop metastatic disease.
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[Journal Article] ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein-Barrvirus infection and microsatellite instability.2012
Author(s)
Abe H, Maeda D, Hino R, Otake Y, Isogai M, Ushiku AS, Matsusaka K, Kunita A, Ushiku T, Uozaki H, Tateishi Y,Hishima T, Iwasaki Y, Ishikawa S, Fukayama M.
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Journal Title
Virchows Arch.
Volume: 461(4)
Pages: 367-77
DOI
Peer Reviewed
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[Journal Article] SOX9 expression and its methylation status in gastric cancer.2012
Author(s)
Sun M, Uozaki H, Hino R, Kunita A, Shinozaki A, Ushiku T, Hibiya T,Takeshita K, Isogai M, Takada K,Fukayama M.
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Journal Title
Virchows Arch.
Volume: 460(3)
Pages: 271-279
DOI
Peer Reviewed
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[Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation Epigenotypes.2011
Author(s)
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R,Uozaki H, Seto Y, Takada K,Aburatani H, Fukayama M.
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Journal Title
Cancer Res.
Volume: 71(23)
Pages: 7187-7197
DOI
Peer Reviewed
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