2012 Fiscal Year Final Research Report
Characteristic of the molecular pathology of the lung adenocarcinomas with mutated KRAS and high-proliferating activity.
| Project/Area Number |
23790411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
WOO Tetsukan 横浜市立大学, 医学研究科, 共同研究員 (90537177)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肺癌 / KRAS / 増殖活性 |
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| Research Abstract |
Our previous studies identified important molecules involved in carcinogenesis of the lung through a comprehensive search for the downstream targets of oncogenic KRAS. The present study investigated such downstream targets by oncogenic KRAS-transduced airway epithelial cells. Results confirmed the changes of the expression levels in almost all target molecules. The expression levels of the three chemokines (CXCL4(PPBP), CCL3, CXCL2) and S100 families were highly elevated in some KRAS-mutated primary lung adenocarcinoma lesions. Protein expression analyses showed the higher expression levels of S100 families in primary lung adenocarcinoma lesions with mutated KRAS and high-proliferating activity.
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[Journal Article] Downregulation of ALDH1A1 expression in non-small cell lung carcinomas-its clinicopathologic and biological significance2013
Author(s)
Okudela K, Woo T, Mitsui H, Suzuki T, Tajiri M, Sakuma Y, Miyagi Y, Tateishi Y, Umeda S, Masuda M, Ohashi K
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Journal Title
Int J Clin Exp Pathol
Volume: 6(1)
Pages: 1-12
URL
Peer Reviewed
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[Journal Article] Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and β-catenin, in primary lung adenocarcinoma--their prognostic significance2012
Author(s)
Okudela K, Woo T, Mitsui H, Tajiri M, Masuda M, Ohashi K
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Journal Title
Pathol Int
Volume: 62(12)
Pages: 792-801
DOI
Peer Reviewed
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[Journal Article] Storomal micropapillary pattern predominant lung adenocarcinoma-a report of two cases2011
Author(s)
Ohe M, Yokose T, Sakuma Y, Osanai S, Hasegawa C, Washimi K, Nawa K, Woo T, Hamanaka R, Nakayama H, Kameda Y, Yamada K, Isobe T
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas2011
Author(s)
Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T
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Journal Title
Pathol Int
Volume: 61(1)
Pages: 19-27
DOI
Peer Reviewed
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