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2012 Fiscal Year Final Research Report

Protective Roles of Epithelial Cells in the Survival of Adult T-Cell Leukemia Cells

Research Project

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Project/Area Number 23790430
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

MIYATAKE Yukiko  北海道大学, 大学院・医学研究科, 助教 (10421984)

Project Period (FY) 2011 – 2012
Keywordsウイルス感染症 / HTLV-1
Research Abstract

Adult T-cell leukemia (ATL) is a highly invasive and intractable T-cell malignancy caused by HTLV-1 infection. We demonstrate here that normal tissue-derived epithelial cells (NECs) exert protective effects on the survival of leukemic cells, which may partially account for high resistance to anti-leukemic therapies in ATL patients. A propensity of leukemia cells to infiltrate into epithelial tissues might produce at least two pathologic outcomes in ATL patients: the survival of leukemia cells through acquisition of cancer stem cell-like phenotypes and the evasion of the host immune response.

  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells.2013

    • Author(s)
      Miyatake, Y., Oliveira, A. L. A., Jarboui, M.A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M
    • Journal Title

      Am.J. Pathol

      Volume: 182 Pages: S0002-9440(13)00099-0

    • Peer Reviewed
  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012

    • Author(s)
      Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., Tanaka, K. and Kasahara, M
    • Journal Title

      Am. J. Pathol

      Volume: 180 Pages: 963-972

    • DOI

      doi:10.1016/j.ajpath.2011.11.012.

    • Peer Reviewed
  • [Presentation] Inactivationof Skint1 in hominoids but not in Old World monkeys2013

    • Author(s)
      Mohamed, R. H., Sutoh, Y., Otsuka, N., Miyatake, Y. and Kasahara, M.
    • Organizer
      第32回日本胸腺研究会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2013-02-09
  • [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与2012

    • Author(s)
      山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
    • Organizer
      第27回日本生殖免疫学会
    • Place of Presentation
      大阪医科大学(高槻市)
    • Year and Date
      2012-12-08
  • [Presentation] Contact with epithelial cells induces cancer stem cell-like properties in adult T-cell leukemia/lymphoma cells2012

    • Author(s)
      Miyatake, Y., Tomaru, U., Hall, W. W. and Kasahara, M.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2012-12-07
  • [Presentation] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair2012

    • Author(s)
      Rania, H. M., Yoshida, S., Miyatake, Y., Otsuka, N. and Kasahara, M.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-12-05
  • [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与2012

    • Author(s)
      山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
    • Organizer
      第45回北海道病理談話会
    • Place of Presentation
      札幌医科大学(札幌市)
    • Year and Date
      2012-10-13
  • [Presentation] 上皮細胞は接着している成人T細胞白血病細胞を細胞静止状態にして保護する2012

    • Author(s)
      宮武由甲子,外丸詩野,笠原正典
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-19
  • [Presentation] 成人T細胞白血病における上皮細 胞の潜在的役割2012

    • Author(s)
      宮武由甲子,Andre, L. A. O,Noreen, S.,大塚紀幸,外丸詩野,Hall , W. W., 笠原正典
    • Organizer
      第92回北海道医学大会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-09-08
  • [Presentation] VLRC defines a population of lamprey lymphocytes distinct from that expressing VLRA or VLRB2012

    • Author(s)
      Sutoh, Y., Kasamatsu, J., Otsuka, N., Miyatake, Y. and Kasahara, M
    • Organizer
      The 12th International Congress of the International Society for Developmental and ComparativeImmunology
    • Place of Presentation
      Fukuoka (Hilton Fukuoka SeaHawk Hotel)
    • Year and Date
      2012-07-10
  • [Presentation] 成人T細胞白血病(ATL)の病態における上皮細胞の役割の検討2012

    • Author(s)
      宮武由甲子,外丸詩野,Noreen Sheehy,石津明洋,William W. Hall,笠原正典
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-04-28
  • [Presentation] New insights into cell-cell interactions between adult T-cell leukemia cells and endothelial cells. The XXV Symposium of the International Association for Comparative Research on Leukemia andRelated Diseases2011

    • Author(s)
      Miyatake, Y., Tomaru, U., Oliveira, L.A., Sheehy, N., Hall, W.W. and Kasahara, M
    • Organizer
      Molecular Pathogenesis and Translational Research in Leukemia and Lymphoma
    • Place of Presentation
      Tokyo (The University of Tokyo)
    • Year and Date
      20110915-17
  • [Presentation] Sromal cells help ATL cells to escape from apoptosis induced by histone deacetylase inhibitors Retrovirology 20118(Suppl 1)2011

    • Author(s)
      Miyatake, Y., Tomaru, U., Oliveira, A.L.,Sheehy, N., Yoshiki, T., Kasahara, M. and Hall, W.W
    • Organizer
      15th International Conference on Human Retrovirology: HTLV and Related Retroviruses Leuven
    • Place of Presentation
      Belgium
    • Year and Date
      20110605-08
  • [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常2011

    • Author(s)
      小原次郎,外丸詩野,鈴木小百合,高橋里美,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      20110428-30
  • [Presentation] プロテアソームの機能異常による病理作用:脂質代謝や脂肪肝との関連性について2011

    • Author(s)
      高橋里美,外丸詩野,合田文,小野綾子,小原次郎,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
    • Organizer
      第100回日本病理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      20110428-30
  • [Presentation] プロテアソーム機能に着目した老化,脂質代謝異常の病態解明2011

    • Author(s)
      外丸詩野,高橋里美,宮武由甲子,小野綾子,小原次郎,紺野沙織,村田茂穂,田中啓二,石津明洋,笠原正典
    • Organizer
      第44回北海道病理談話会
    • Place of Presentation
      旭川市国際会議場(北海道)
    • Year and Date
      2011-09-10
  • [Remarks]

    • URL

      http://www.path1-hokudai.jp/path1/Welcome.html

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Published: 2014-09-25  

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