Protective Roles of Epithelial Cells in the Survival of Adult T-Cell Leukemia Cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: MIYATAKE Yukiko 北海道大学, 大学院・医学研究科, 助教 (10421984)
• Project Period (FY): 2011 – 2012
• Keywords: ウイルス感染症 / HTLV-1

Research Abstract

Adult T-cell leukemia (ATL) is a highly invasive and intractable T-cell malignancy caused by HTLV-1 infection. We demonstrate here that normal tissue-derived epithelial cells (NECs) exert protective effects on the survival of leukemic cells, which may partially account for high resistance to anti-leukemic therapies in ATL patients. A propensity of leukemia cells to infiltrate into epithelial tissues might produce at least two pathologic outcomes in ATL patients: the survival of leukemia cells through acquisition of cancer stem cell-like phenotypes and the evasion of the host immune response.

Research Products

• [Journal Article] Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. (2013)
  • Author(s): Miyatake, Y., Oliveira, A. L. A., Jarboui, M.A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M
  • Journal Title: Am.J. Pathol Volume: 182 Pages: S0002-9440(13)00099-0
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities (2012)
  • Author(s): Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., Tanaka, K. and Kasahara, M
  • Journal Title: Am. J. Pathol Volume: 180 Pages: 963-972
  • DOI: doi:10.1016/j.ajpath.2011.11.012.
  • Peer Reviewed
• [Presentation] Inactivationof Skint1 in hominoids but not in Old World monkeys (2013)
  • Author(s): Mohamed, R. H., Sutoh, Y., Otsuka, N., Miyatake, Y. and Kasahara, M.
  • Organizer: 第32回日本胸腺研究会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2013-02-09
• [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与 (2012)
  • Author(s): 山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
  • Organizer: 第27回日本生殖免疫学会
  • Place of Presentation: 大阪医科大学(高槻市)
  • Year and Date: 2012-12-08
• [Presentation] Contact with epithelial cells induces cancer stem cell-like properties in adult T-cell leukemia/lymphoma cells (2012)
  • Author(s): Miyatake, Y., Tomaru, U., Hall, W. W. and Kasahara, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際展示場(兵庫県)
  • Year and Date: 2012-12-07
• [Presentation] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair (2012)
  • Author(s): Rania, H. M., Yoshida, S., Miyatake, Y., Otsuka, N. and Kasahara, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与 (2012)
  • Author(s): 山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
  • Organizer: 第45回北海道病理談話会
  • Place of Presentation: 札幌医科大学(札幌市)
  • Year and Date: 2012-10-13
• [Presentation] 上皮細胞は接着している成人T細胞白血病細胞を細胞静止状態にして保護する (2012)
  • Author(s): 宮武由甲子,外丸詩野,笠原正典
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] 成人T細胞白血病における上皮細 胞の潜在的役割 (2012)
  • Author(s): 宮武由甲子,Andre, L. A. O,Noreen, S.,大塚紀幸,外丸詩野,Hall , W. W., 笠原正典
  • Organizer: 第92回北海道医学大会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-08
• [Presentation] VLRC defines a population of lamprey lymphocytes distinct from that expressing VLRA or VLRB (2012)
  • Author(s): Sutoh, Y., Kasamatsu, J., Otsuka, N., Miyatake, Y. and Kasahara, M
  • Organizer: The 12th International Congress of the International Society for Developmental and ComparativeImmunology
  • Place of Presentation: Fukuoka (Hilton Fukuoka SeaHawk Hotel)
  • Year and Date: 2012-07-10
• [Presentation] 成人T細胞白血病(ATL)の病態における上皮細胞の役割の検討 (2012)
  • Author(s): 宮武由甲子,外丸詩野,Noreen Sheehy,石津明洋,William W. Hall,笠原正典
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2012-04-28
• [Presentation] New insights into cell-cell interactions between adult T-cell leukemia cells and endothelial cells. The XXV Symposium of the International Association for Comparative Research on Leukemia andRelated Diseases (2011)
  • Author(s): Miyatake, Y., Tomaru, U., Oliveira, L.A., Sheehy, N., Hall, W.W. and Kasahara, M
  • Organizer: Molecular Pathogenesis and Translational Research in Leukemia and Lymphoma
  • Place of Presentation: Tokyo (The University of Tokyo)
  • Year and Date: 20110915-17
• [Presentation] Sromal cells help ATL cells to escape from apoptosis induced by histone deacetylase inhibitors Retrovirology 20118(Suppl 1) (2011)
  • Author(s): Miyatake, Y., Tomaru, U., Oliveira, A.L.,Sheehy, N., Yoshiki, T., Kasahara, M. and Hall, W.W
  • Organizer: 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses Leuven
  • Place of Presentation: Belgium
  • Year and Date: 20110605-08
• [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常 (2011)
  • Author(s): 小原次郎,外丸詩野,鈴木小百合,高橋里美,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20110428-30
• [Presentation] プロテアソームの機能異常による病理作用:脂質代謝や脂肪肝との関連性について (2011)
  • Author(s): 高橋里美,外丸詩野,合田文,小野綾子,小原次郎,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 20110428-30
• [Presentation] プロテアソーム機能に着目した老化,脂質代謝異常の病態解明 (2011)
  • Author(s): 外丸詩野,高橋里美,宮武由甲子,小野綾子,小原次郎,紺野沙織,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第44回北海道病理談話会
  • Place of Presentation: 旭川市国際会議場(北海道)
  • Year and Date: 2011-09-10
• [Remarks]
  • URL: http://www.path1-hokudai.jp/path1/Welcome.html