2013 Fiscal Year Final Research Report
The effect of extracellular ATP-induced neutrophil on endotoxin hepatitis in mice
| Project/Area Number |
23790436
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Niigata University of Health and Welfare (2013)
Niigata University (2011-2012) |
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Principal Investigator |
KAWAMURA Hiroki 新潟医療福祉大学, 医療技術学部, 講師 (20333495)
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| Project Period (FY) |
2011 – 2013
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| Keywords | マクロファージ / ATP / 好中球 / MIP-2 |
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| Research Abstract |
Extracellular ATP leads to immune responses in a wide spectrum of cell types (e.g., macrophages, T cells) and tissues. Our previous study shows that extracellular ATP-stimulated macrophages produce MIP-2. Thus, we investigated the role of ATP-mediated inflammatory response by macrophages in LPS-induced endotoxin shock model mouse. This study indicated that an increased production of reactive oxygen species by ATP-stimulated macrophages activates the signalling pathways that promote MIP-2 production which, in turn, induces neutrophil migration. Unfortunately, this pathway did not affect pathogenic mechanism in LPS-induced endotoxin shock model mouse.
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