2012 Fiscal Year Final Research Report
Researching the mechanism of cancer-associated epithelial cells
| Project/Area Number |
23790455
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
SHIRAKIHARA Takuya 独立行政法人国立がん研究センター, 研究所, 研究員 (30548756)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞 |
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| Research Abstract |
We have previously reported that EMT-acquired normal epithelial cells facilitated invasion of cancer cells, when they mixed and cultured together. A number of specific genes expressed in these cells were identified by using microarray analysis. ITGA3 was highly expressed in poorly-differentiated breast cancer tissues and the neutralizing antibody of ITGA3 suppressed invasion of EMT-acquired cells.
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