2012 Fiscal Year Final Research Report
Investigation of the role of antioxidant protein PrxI against tuberculosis
| Project/Area Number |
23790466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
OKUMURA Kayo 帯広畜産大学, 畜産学部, 助教 (70415561)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細菌 / 感染症 |
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| Research Abstract |
To determine whether PrxI is essential for the host defense against tuberculosis, susceptibility of PrxI-deficient (PrxI KO) mice to Mycobacterium tuberculosis (Mtb) was compared to wild-type mice in vivo. We observed that PrxI KO mouse infected that with virulent Mtb survived significantly shorter as compared to the wild-type controls. Also we found that PrxI bound to Mtb specific protein.
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