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2012 Fiscal Year Final Research Report

Analysis of the Shigella.Host defense interaction

Research Project

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Project/Area Number 23790471
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases (2012)
The University of Tokyo (2011)

Principal Investigator

OGAWA Michinaga  国立感染症研究所, 細菌第一部, 室長 (80361624)

Project Period (FY) 2011 – 2012
Keywords感染免疫 / 赤痢菌
Research Abstract

We demonstrated that Tecpr1 is an essential component of the WIPI-2-Tecpr1- Atg5-dependent pathway in selective autophagy for Shigella, Salmonella, GAS, aggresomes, and damaged mitochondria. Next we revealed that Shigella deliver a caspase-4-specific inhibitor, OspC3, to antagonize epithelial cell death and promote infection.

  • Research Products

    (38 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 13 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] bacterial caspase inhibitor antagonizes inflammatory cell death and promotes epithelial infection.2013

    • Author(s)
      Kobayashi, T., Ogawa, M., Sanada, T., Mimuro, H., Kim, M., Ashida, H., Akakura, R., Yoshida, M., Kawalec, M., Reichhart, J., Mizushima, T. & Sasakawa, C
    • Journal Title

      Cell Host Microbe

      Volume: 13 Pages: 570-583

    • DOI

      DOI:10.1016/j.chom.2013.04.012

    • Peer Reviewed
  • [Journal Article] Shigella Targets Epithelial Tricellular Junctions and Uses a Noncanonical Clathrin-Dependent Endocytic Pathway to Spread Between Cells.2012

    • Author(s)
      Fukumatsu, M., Ogawa, M., Arakawa, S., Suzuki, M., Nakayama, K., Shimizu, S., Kim, M., Mimuro, H. & Sasakawa, C
    • Journal Title

      Cell Host Microbe

      Volume: 11 Pages: 325-336

    • DOI

      DOI:10.1016/j.chom.2012.03.001.

    • Peer Reviewed
  • [Journal Article] The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.2012

    • Author(s)
      Suzuki, M., Ogawa, M., Oyama, A., Ashida, H., Kobayashi, T., Koyama, T., Nagai, S., Shibata, Y., Gohda, J., Inoue, J., Mizushima, T. & Sasakawa, C
    • Journal Title

      Nature

      Volume: 483 Pages: 623-626

    • DOI

      DOI:10.1038/nature10894

    • Peer Reviewed
  • [Journal Article] A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells.2012

    • Author(s)
      Sanada, T., Kim, M., Mimuro, H., Ashida, H., Ogawa, M., Mizushima, T., Sasakawa, C
    • Journal Title

      Virulence

      Volume: 3 Pages: 518-520

    • DOI

      DOI:10.4161/viru.21451

    • Peer Reviewed
  • [Journal Article] Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway.2012

    • Author(s)
      Fukumatsu, M., Ogawa, M., Kim, M., Mimuro, H., Sasakawa, C
    • Journal Title

      Virulence

      Volume: 3 Pages: 515-517

    • DOI

      DOI:10.4161/viru.21740

    • Peer Reviewed
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy.2012

    • Author(s)
      Klionsky, DJ. et al.
    • Journal Title

      Autophagy

      Volume: 8 Pages: 445-544

    • DOI

      DOI:10.4161/auto.19496

    • Peer Reviewed
  • [Journal Article] 病原細菌を標的とした選択的オートファジーの分子メカニズム2012

    • Author(s)
      小川道永
    • Journal Title

      生物工学学会誌

      Volume: 90 Pages: 200

    • URL

      https://www.sbj.or.jp/wp-content/uploads/file/sbj/9004/9004_biomedia_4.pdf

  • [Journal Article] 病原細菌を標的としたオートファジーにおける新規認識機構2012

    • Author(s)
      小川道永
    • Journal Title

      化学と生物

      Volume: 50 Pages: 160-162

    • URL

      http://www.jsbba.or.jp/pub/journal_kasei/kasei_contents/vol50_3_2012.html

  • [Journal Article] 細胞侵入性細菌のオートファジーによる認識機構2012

    • Author(s)
      小川道永
    • Journal Title

      炎症と免疫

      Volume: 20 Pages: 151-156

  • [Journal Article] A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens.2011

    • Author(s)
      Ogawa, M., Yoshikawa, Y., Kobayashi, T., Mimuro, H., Fukumatsu, M., Kiga, K., Piao, Z., Ashida, H., Yoshida, M., Kakuta, S., Koyama, T., Goto, Y., Nagatake, T., Nagai, S., Kiyono, H., Kawalec, M., Reichhart, J. M. & Sasakawa, C
    • Journal Title

      Cell Host Microbe

      Volume: 9 Pages: 376-389

    • DOI

      DOI:10.1016/j.chom.2011.04.010

    • Peer Reviewed
  • [Journal Article] Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure.2011

    • Author(s)
      Ogawa, M., Yoshikawa, Y., Mimuro, H., Hain, T., Chakraborty, T. & Sasakawa, C
    • Journal Title

      Autophagy

      Volume: 7 Pages: 310-314

    • DOI

      DOI:10.4161/auto.7.3.14581

    • Peer Reviewed
  • [Journal Article] Manipulation of autophagy by bacteria for their own benefit.2011

    • Author(s)
      Ogawa, M., Mimuro, H., Yoshikawa, Y., Ashida, H. & Sasakawa, C
    • Journal Title

      Microbiol Immunol

      Volume: 55 Pages: 459-471

    • DOI

      DOI:10.1111/j.1348-0421.2011.00343.x

    • Peer Reviewed
  • [Journal Article] The role of Tecpr1 in selective autophagy as a cargo receptor.2011

    • Author(s)
      Ogawa, M. & Sasakawa, C
    • Journal Title

      Autophagy

      Volume: 7 Pages: 1389-91

    • DOI

      DOI:10.4161/auto.7.11.17151

    • Peer Reviewed
  • [Journal Article] Bacteria and host interactions in the gut epithelial barrier.2011

    • Author(s)
      Ashida, H., Ogawa, M., Kim, M., Mimuro, H. & Sasakawa, C
    • Journal Title

      Nat chem Biol

      Volume: 8 Pages: 36-45

    • DOI

      DOI:10.1038/nchembio.741

    • Peer Reviewed
  • [Journal Article] Host-pathogen interactions: Cell death and infection: A double-edged sword for host and pathogen survival.2011

    • Author(s)
      Ashida, H., Mimuro, H, Ogawa, M., Kobayashi, T., Sanada, T., Kim, M. & Sasakawa, C
    • Journal Title

      J Cell Biol

      Volume: 195 Pages: 931-42

    • DOI

      DOI:10.1083/jcb.201108081

    • Peer Reviewed
  • [Journal Article] Shigella are versatile mucosal pathogens that circumvent the host innate immune system.2011

    • Author(s)
      Ashida, H., Ogawa, M., Mimuro, H., Kobayashi, T., Sanada, T. & Sasakawa, C
    • Journal Title

      Curr Opin Immunol

      Volume: 23 Pages: 448-55

    • DOI

      DOI:10.1016/j.coi.2011.06.001

    • Peer Reviewed
  • [Journal Article] 赤痢菌の自然免疫回避機構2011

    • Author(s)
      小川道永、笹川千尋
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 600-608

    • URL

      http://www.kahyo.com/item/M201111-565

  • [Presentation] 赤痢菌の感染戦略~宿主細胞の感染性細胞死に抗うカスパーゼ阻害エフェクター~2013

    • Author(s)
      小林泰良,小川道永,真田貴人,三室仁美,笹川千尋
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉(幕張)
    • Year and Date
      2013-03-19
  • [Presentation] Tecpr1 による選択的オートファジー認識機構2013

    • Author(s)
      小川道永
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉(幕張)
    • Year and Date
      2013-03-18
  • [Presentation] Selective autophagy for intracellular bacteria2012

    • Author(s)
      小川道永
    • Organizer
      11th Korea-Japan International Symposium on Microbiology (XI-KJISM)
    • Place of Presentation
      Buyeo, Korea
    • Year and Date
      20120913-14
  • [Presentation] 病原細菌と宿主との攻防~感染生物学のススメ~2012

    • Author(s)
      小川道永
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
  • [Presentation] 赤痢菌の感染戦略~宿主細胞の炎症性細胞死に抗うカスパーゼ阻害エフェクター~2012

    • Author(s)
      小林泰良,小川道永,三室仁美,笹川千尋
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
  • [Presentation] 赤痢菌III型分泌OspIによる炎症抑制機構の新規メカニズムの解明2012

    • Author(s)
      真田貴人、KimMinsoo、三室仁美、鈴木仁人、小川道永、小山晃穂、芦田浩、小林泰良、小山智洋、長井伸也、柴田佑里、合田仁、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京(お台場)
    • Year and Date
      2012-10-11
  • [Presentation] 赤痢菌の上皮細胞内生存戦略としてのパイロプトーシス抑制機構2012

    • Author(s)
      小林泰良、小川道永、三室仁美、笹川千尋
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京(お台場)
    • Year and Date
      2012-10-11
  • [Presentation] A bacterial effector hijacks a novel Caspase-4 dependent epithelial cell death pathway2012

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
  • [Presentation] A bacterial effector deamidates Ubc13 to dampen the inflammatory response2012

    • Author(s)
      真田貴人、キムミンス、三室仁美、鈴木仁人、小山明穂、芦田浩、小川道永、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2012

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
  • [Presentation] Tecpr1 in Shigella-selective autophagy2012

    • Author(s)
      小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      2^<nd> International symposium, Microbes For Health
    • Place of Presentation
      パリ
    • Year and Date
      2011-12-01
  • [Presentation] 病原細菌としたオートファジー認識機構と病原細菌によるその回避機構2011

    • Author(s)
      小川道永
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] 赤痢菌のタイプIIIエフェクターによるパイロプトーシス回避機構2011

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
  • [Presentation] 赤痢菌における細胞間拡散機構2011

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
  • [Presentation] Shigella flexneri hijack Caspse-4 to evade Pyroptosis2011

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      IMSUT/RCAST . Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Year and Date
      2011-09-17
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2011

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      IMSUT/RCAST . Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Year and Date
      2011-09-17
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
  • [Presentation] The role of Tecpr1-depedent Selective autophagic pathway in targeting bacterial pathogens2011

    • Author(s)
      小川道永、笹川千尋
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2011

    • Author(s)
      福松真、小川道永、鈴木仁人、三室仁美、笹川千尋
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
  • [Remarks]

    • URL

      http://first.lifesciencedb.jp/archives/2966

URL: 

Published: 2014-09-25  

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