2013 Fiscal Year Final Research Report
Analysis of novel pathway for inflammatory responses induced by Mycoplasma pneumonia
| Project/Area Number |
23790488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | マイコプラズマ / マイコプラズマ肺炎 / Toll-like Receptor / オートファジー / 自然免疫 / リポプロテイン / 細胞接着 / 滑走運動 |
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| Research Abstract |
Mycoplasma pneumoniae induced pneumonia in human. Lipoproteins of M. pneumoniae and its receptor Toll-like Receptor (TLR) 2 were have been thought to be important to induce inflammation. However, in this study, we demonstrated that M. pneumoniae induced inflammatory responses through TLR2-independent pathway. TLR4 and autophagy played important roles in the induction of TLR2-independent pathway. Moreover, transposon mutagenesis revealed that cytadherence of M. pneumoniae was important factor for the induction. Overall, these results suggest that cytadherence of M. pneumoniae induces inflammatory responses through TLR4 and autophagy.
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Research Products
(14 results)
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[Journal Article] Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice2013
Author(s)
Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I
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Journal Title
J Reprod Immunol
Volume: 100(2)
Pages: 118-127
DOI
Peer Reviewed
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[Journal Article] Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 22012
Author(s)
Kurokawa K, Ryu KH, Ichikawa R, Masuda A, Kim MS, Lee H, Chae JH, Shimizu T, Saitoh T, Kuwano K, Akira S, Dohmae N, Nakayama H, Lee BL
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Journal Title
J. Biol. Chem
Volume: 287(16)
Pages: 13170-13180
DOI
Peer Reviewed
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